Ugawa Satoko, Akagi Satoshi, Ejiri Kentaro, Nakamura Kazufumi, Ito Hiroshi
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan.
Department of Cardiology, Kagawa Prefectural Central Hospital, Takamatsu 760-8557, Japan.
Life (Basel). 2022 May 5;12(5):684. doi: 10.3390/life12050684.
Dual-energy computed tomography (DECT) is a promising technique for the assessment of the lung perfused blood volume (LPBV) in the lung parenchyma. This study was performed to compare the LPBV by DECT of patients with pulmonary hypertension (PH) and controls and to evaluate the association between the LPBV and the perfusion ratio derived by lung perfusion scintigraphy. This study involved 45 patients who underwent DECT (25 patients with PH and 20 controls). We measured the total LPBV and distribution of the LPBV in each lung. The total LPBV was significantly lower in the PH group than the control group (38 ± 9 vs. 45 ± 8 HU, p = 0.024). Significant differences were observed between the LPBV of the upper lung of the PH and control groups (34 ± 10 vs. 47 ± 10, p = 0.021 and 37 ± 10 vs. 47 ± 8, p < 0.001). A significant correlation was observed between the LPBV and the lung perfusion scintigraphy. A lower total LPBV and lower LPBV of the upper lung as detected by DECT might be specific findings of PH.
双能量计算机断层扫描（DECT）是一种用于评估肺实质内肺灌注血容量（LPBV）的有前景的技术。本研究旨在比较肺动脉高压（PH）患者和对照组通过DECT测得的LPBV，并评估LPBV与肺灌注闪烁显像得出的灌注率之间的关联。本研究纳入了45例行DECT检查的患者（25例PH患者和20例对照组）。我们测量了每个肺的总LPBV及LPBV分布。PH组的总LPBV显著低于对照组（38±9 vs. 45±8 HU，p = 0.024）。PH组和对照组上肺的LPBV之间观察到显著差异（34±10 vs. 47±10，p = 0.021以及37±10 vs. 47±8，p < 0.001）。LPBV与肺灌注闪烁显像之间观察到显著相关性。通过DECT检测到的较低总LPBV和上肺较低LPBV可能是PH的特异性表现。
