Islam Tarequl, Rabbee Muhammad Fazle, Choi Jinhee, Baek Kwang-Hyun
Department of Biotechnology, Yeungnam University, Gyeongsan 38541, Korea.
Metabolites. 2022 Apr 27;12(5):397. doi: 10.3390/metabo12050397.
Microbes produce a diverse range of secondary metabolites in response to various environmental factors and interspecies competition. This enables them to become superior in a particular environment. Bacilysin, a dipeptide antibiotic produced by species, is active against a broad range of microorganisms. Because of its simple structure and excellent mode of action, i.e., through the inhibition of glucosamine 6-phosphate synthase, it has drawn the attention of researchers. In addition, it acts as a pleiotropic signaling molecule that affects different cellular activities. However, all species are not capable of producing bacilysin. The biosynthesis of bacilysin by species is not uniform throughout the population; specificity and heterogeneity at both the strain and species levels has been observed. This review discusses how bacilysin is biosynthesized by species, the regulators of its biosynthesis, its importance in the host, and the abiotic factors affecting bacilysin production.
微生物会根据各种环境因素和种间竞争产生多种次级代谢产物。这使它们能够在特定环境中占据优势。芽孢杆菌素是由某些物种产生的一种二肽抗生素，对多种微生物具有活性。由于其结构简单且作用方式优异，即通过抑制6-磷酸葡糖胺合酶，它引起了研究人员的关注。此外，它还作为一种多效性信号分子，影响不同的细胞活动。然而，并非所有物种都能产生芽孢杆菌素。某些物种中芽孢杆菌素的生物合成在整个群体中并不一致；在菌株和物种水平上都观察到了特异性和异质性。本综述讨论了某些物种如何生物合成芽孢杆菌素、其生物合成的调节因子、它在宿主中的重要性以及影响芽孢杆菌素产生的非生物因素。
