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与吡嗪、喹喔啉或吩嗪的铁（III）配合物的平衡研究及其在甲醇中的儿茶酚酶活性。

Equilibrium Studies of Iron (III) Complexes with Either Pyrazine, Quinoxaline, or Phenazine and Their Catecholase Activity in Methanol.

机构信息

División de Ciencias de la Vida (DICIVA), Campus Irapuato-Salamanca, Universidad de Guanajuato, Ex Hacienda El Copal, Carretera Irapuato-Silao Km. 9, Irapuato 36500, Mexico.

Centro Universitario de los Lagos, Universidad de Guadalajara, Enrique Díaz de León 1144, Col. Paseos de la Montaña, Lagos de Moreno 47460, Mexico.

出版信息

Molecules. 2022 May 19;27(10):3257. doi: 10.3390/molecules27103257.

DOI:10.3390/molecules27103257
PMID:35630733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9143456/
Abstract

Currently, catalysts with oxidative activity are required to create valuable chemical, agrochemical, and pharmaceutical products. The catechol oxidase activity is a model reaction that can reveal new oxidative catalysts. The use of complexes as catalysts using iron (III) and structurally simple ligands such as pyrazine (pz), quinoxaline (qx), and phenazine (fz) has not been fully explored. To characterize the composition of the solution and identify the abundant species which were used to catalyze the catechol oxidation, the distribution diagrams of these species were obtained by an equilibrium study using a modified Job method in the HypSpec software. This allows to obtain also the UV-vis spectra calculated and the formation constants for the mononuclear and binuclear complexes with Fe including: [Fe(pz)], [Fe(pz)], [Fe(qx)], [Fe(qx)], [Fe(fz)], and [Fe(fz)]. The formation constants obtained were log β = 3.2 ± 0.1, log β = 6.9 ± 0.1, log β = 4.4 ± 0.1, log β = 8.3 ± 0.1, log β = 6.4 ± 0.2, and log β = 9.9 ± 0.2, respectively. The determination of the catechol oxidase activity for these complexes did not follow a traditional Michaelis-Menten behavior.

摘要

目前，需要具有氧化活性的催化剂来制造有价值的化学、农用化学品和药物产品。儿茶酚氧化酶活性是一种可以揭示新的氧化催化剂的模型反应。使用铁（III）和结构简单的配体（如吡嗪（pz）、喹喔啉（qx）和吩嗪（fz））作为催化剂的配合物的使用尚未得到充分探索。为了表征溶液的组成并确定用于催化儿茶酚氧化的丰富物种，使用 HypSpec 软件中的改进 Job 法进行平衡研究获得了这些物种的分布图。这还允许获得计算的 UV-vis 光谱和包含 Fe 的单核和双核配合物的形成常数：[Fe(pz)]、[Fe(pz)]、[Fe(qx)]、[Fe(qx)]、[Fe(fz)]和[Fe(fz)]。获得的形成常数分别为 log β = 3.2 ± 0.1、log β = 6.9 ± 0.1、log β = 4.4 ± 0.1、log β = 8.3 ± 0.1、log β = 6.4 ± 0.2 和 log β = 9.9 ± 0.2。这些配合物的儿茶酚氧化酶活性的测定不符合传统的米氏-门坦行为。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/9143456/3b24f02e026e/molecules-27-03257-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/9143456/7bf5978a7536/molecules-27-03257-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/9143456/08c47b517cf6/molecules-27-03257-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/9143456/a762be44607f/molecules-27-03257-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/9143456/a6542ea2966a/molecules-27-03257-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/9143456/3b24f02e026e/molecules-27-03257-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/9143456/7bf5978a7536/molecules-27-03257-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/9143456/08c47b517cf6/molecules-27-03257-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/9143456/a762be44607f/molecules-27-03257-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/9143456/a6542ea2966a/molecules-27-03257-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/9143456/3b24f02e026e/molecules-27-03257-g005.jpg

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