Division of Endocrinology, Department of Medicine, Centre de Recherche du CHUS, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.
Unité de Biologie Fonctionnelle et Adaptative, UMR 8251 CNRS, Université Paris Cité, F-75013 Paris, France.
Nutrients. 2022 May 12;14(10):2039. doi: 10.3390/nu14102039.
Plant-derived polyphenols flavonoids are increasingly being recognized for their medicinal potential. These bioactive compounds derived from plants are gaining more interest in ameliorating adverse health risks because of their low toxicity and few side effects. Among them, therapeutic approaches demonstrated the efficacy of catechins, a major group of flavonoids, in reverting several aspects of Down syndrome, the most common genomic disorder that causes intellectual disability. Down syndrome is characterized by increased incidence of developing Alzheimer's disease, obesity, and subsequent metabolic disorders. In this focused review, we examine the main effects of catechins on comorbidities linked with Down syndrome. We also provide evidence of catechin effects on DYRK1A, a dosage-sensitive gene encoding a protein kinase involved in brain defects and metabolic disease associated with Down syndrome.
植物来源的多酚类黄酮因其药用潜力而越来越受到关注。这些源自植物的生物活性化合物因其低毒性和很少的副作用而在改善不良健康风险方面引起了更多的兴趣。其中，治疗方法表明儿茶素（一种主要的黄酮类化合物）在逆转唐氏综合征（一种导致智力障碍的最常见的基因组疾病）的几个方面具有疗效。唐氏综合征的特点是阿尔茨海默病、肥胖和随后的代谢紊乱发病率增加。在本次重点综述中，我们研究了儿茶素对与唐氏综合征相关的合并症的主要影响。我们还提供了儿茶素对 DYRK1A 的作用的证据，DYRK1A 是一个剂量敏感基因，编码一种蛋白激酶，与唐氏综合征相关的脑缺陷和代谢疾病有关。
