Tsyganov Matvey M, Ibragimova Marina K, Gaptulbarova Kseniya A, Tsydenova Irina A, Dolgasheva Daria S, Garbukov Evgeniy Y, Frolova Anastasia A, Slonimskaya Elena M, Litvyakov Nikolai V
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 5, Kooperativny Street, 634050 Tomsk, Russia.
Biological Institute, Tomsk State University, 36 Lenin Ave., 634050 Tomsk, Russia.
Pharmaceutics. 2022 Apr 27;14(5):948. doi: 10.3390/pharmaceutics14050948.
One of the important reasons for the ineffectiveness of chemotherapy in breast cancer (BC) is considered to be the formation of a multidrug resistance phenotype in tumour cells, which is caused by the expression of energy-dependent ABC transporters. The aim of this work was to assess chromosomal aberrations and the level of transcripts of all 49 known ABC transporter genes in breast tumours.
The study included 129 patients with breast cancer. A microarray study of all tumour samples was carried out on microchips.
This study established that the presence of a deletion in genes and is associated with an objective response to treatment ( ≤ 0.05). A decrease in the expression of genes was associated with a good response to chemotherapy, whereas an increase in expression caused the progression and stabilization of the tumour. Analysis of metastatic-free survival rates showed that the presence of and deletions was associated with 100% survival (log-rank test = 0.01 and = 0.03).
The study showed that the aberrant state of ABC transporter genes, as well as a decrease in the expression of these genes, is a predictor of the effectiveness of therapeutic treatment and a potential prognostic marker of metastatic survival.
化疗对乳腺癌（BC）无效的一个重要原因被认为是肿瘤细胞中形成了多药耐药表型，这是由能量依赖性ABC转运蛋白的表达引起的。这项工作的目的是评估乳腺肿瘤中所有49个已知ABC转运蛋白基因的染色体畸变和转录本水平。
该研究纳入了129例乳腺癌患者。对所有肿瘤样本进行了微芯片微阵列研究。
本研究确定基因和中的缺失与治疗的客观反应相关（≤0.05）。基因表达的降低与化疗的良好反应相关，而表达的增加导致肿瘤进展和稳定。无转移生存率分析表明，和缺失的存在与100%生存率相关（对数秩检验=0.01和=0.03）。
该研究表明，ABC转运蛋白基因的异常状态以及这些基因表达的降低是治疗有效性的预测指标和转移生存的潜在预后标志物。
