Oluwole David O, Coleman Lucy, Buchanan William, Chen Tao, La Ragione Roberto M, Liu Lian X
Chemical and Process Engineering Department, Faculty of Engineering and Physical Science, University of Surrey, Guildford GU2 7XH, UK.
Phytoceutical Limited, Midhurst, West Sussex GU29 9DJ, UK.
Pharmaceutics. 2022 May 9;14(5):1021. doi: 10.3390/pharmaceutics14051021.
The rapid rise in the health burden associated with chronic wounds is of great concern to policymakers, academia, and industry. This could be attributed to the devastating implications of this condition, and specifically, chronic wounds which have been linked to invasive microbial infections affecting patients' quality of life. Unfortunately, antibiotics are not always helpful due to their poor penetration of bacterial biofilms and the emergence of antimicrobial resistance. Hence, there is an urgent need to explore antibiotics-free compounds/formulations with proven or potential antimicrobial, anti-inflammatory, antioxidant, and wound healing efficacy. The mechanism of antibiotics-free compounds is thought to include the disruption of the bacteria cell structure, preventing cell division, membrane porins, motility, and the formation of a biofilm. Furthermore, some of these compounds foster tissue regeneration by modulating growth factor expression. In this review article, the focus is placed on a number of non-antibiotic compounds possessing some of the aforementioned pharmacological and physiological activities. Specific interest is given to , curcumin, cinnamaldehyde, polyhexanide, retinoids, ascorbate, tocochromanols, and chitosan. These compounds (when alone or in formulation with other biologically active molecules) could be a dependable alternative in the management or prevention of chronic wounds.
慢性伤口相关健康负担的迅速增加引起了政策制定者、学术界和产业界的高度关注。这可能归因于这种疾病的破坏性影响，特别是慢性伤口与侵袭性微生物感染有关，影响患者的生活质量。不幸的是，由于抗生素对细菌生物膜的渗透性差以及抗菌耐药性的出现，抗生素并不总是有用。因此，迫切需要探索具有已证实或潜在抗菌、抗炎、抗氧化和伤口愈合功效的无抗生素化合物/制剂。无抗生素化合物的作用机制被认为包括破坏细菌细胞结构、阻止细胞分裂、膜孔蛋白、运动性以及生物膜的形成。此外，其中一些化合物通过调节生长因子表达促进组织再生。在这篇综述文章中，重点关注了一些具有上述某些药理和生理活性的非抗生素化合物。特别关注的是姜黄素、肉桂醛、聚己缩胍、类视黄醇、抗坏血酸盐、生育三烯酚和壳聚糖。这些化合物（单独使用或与其他生物活性分子制成制剂时）可能是管理或预防慢性伤口的可靠替代品。
