Arnold Marie-Luise, Heinemann Falko M, Oesterreich Simon, Wilde Benjamin, Gäckler Anja, Goldblatt David, Spriewald Bernd M, Horn Peter A, Witzke Oliver, Lindemann Monika
Department of Internal Medicine, Friedrich-Alexander University Erlangen-Nürnberg, Krankenhausstraße 12, 91054 Erlangen, Germany.
Institute for Transfusion Medicine, University Hospital, Virchowstraße 179, 45147 Essen, Germany.
Vaccines (Basel). 2022 May 5;10(5):725. doi: 10.3390/vaccines10050725.
Several polymorphisms within Fc receptors (FCR) have been described, some of which correlate with allograft function. In the current study, we determined three Fcγ receptor and five Fcα receptor dimorphisms in 47 kidney transplant recipients who had been vaccinated against Streptococcus pneumoniae. We analyzed if FCR genotypes correlated with pneumococcal antibodies and their serotype-specific opsonophagocytic function, tested prior to and at months 1 and 12 post-vaccination. In parallel, we assessed antibodies against HLA and MICA and determined kidney function. We observed that IgG2 antibodies against pneumococci at months 1 and 12 after vaccination and IgA antibodies at month 1 differed significantly between the carriers of the three genotypes of FCGR3A rs396991 (V158F, p = 0.02; 0.04 and 0.009, respectively). Moreover, the genotype of FCGR3A correlated with serotype-specific opsonophagocytic function, reaching statistical significance (p < 0.05) at month 1 for 9/13 serotypes and at month 12 for 6/13 serotypes. Heterozygotes for FCGR3A had the lowest antibody response after pneumococcal vaccination. On the contrary, heterozygotes tended to have more antibodies against HLA class I and impaired kidney function. Taken together, our current data indicate that heterozygosity for FCGR3A may be unfavorable in kidney transplant recipients.
已描述了Fc受体（FCR）内的几种多态性，其中一些与同种异体移植功能相关。在本研究中，我们测定了47名接种过肺炎链球菌疫苗的肾移植受者的三种Fcγ受体和五种Fcα受体二态性。我们分析了FCR基因型是否与肺炎球菌抗体及其血清型特异性调理吞噬功能相关，在接种疫苗前以及接种后1个月和12个月进行了检测。同时，我们评估了抗HLA和MICA的抗体，并测定了肾功能。我们观察到，接种疫苗后1个月和12个月时针对肺炎球菌的IgG2抗体以及接种后1个月时的IgA抗体在FCGR3A rs396991三种基因型的携带者之间存在显著差异（V158F，p分别为0.02；0.04和0.009）。此外，FCGR3A的基因型与血清型特异性调理吞噬功能相关，在接种后1个月时对13种血清型中的9种达到统计学显著性（p < 0.05），在接种后12个月时对13种血清型中的6种达到统计学显著性。FCGR3A的杂合子在肺炎球菌疫苗接种后的抗体反应最低。相反，杂合子往往有更多针对HLA I类的抗体且肾功能受损。综上所述，我们目前的数据表明，FCGR3A的杂合性在肾移植受者中可能是不利的。
