Grupo de Neurologia Cognitiva e do Comportamento, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Programa de Pós-Graduação em Neurociências, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
Neurol Sci. 2022 Sep;43(9):5363-5368. doi: 10.1007/s10072-022-06160-2. Epub 2022 May 28.
Episodic memory impairment may occur in progressive supranuclear palsy (PSP). However, it remains uncertain whether this is due to executive dysfunction or to the involvement of brain areas responsible for memory.
To investigate the specific brain regions underlying episodic memory impairment in PSP.
Twenty-one patients with PSP and 20 healthy controls underwent the Figure Memory Test (FMT) from the Brief Cognitive Screening Battery and brain MRI. We explored correlations between gray matter volumes and memory scores in PSP patients, adjusting for age and performance on the Frontal Assessment Battery.
PSP patients performed worse than controls (p < 0.001) on delayed recall in the FMT. Delayed recall scores correlated to bilateral hippocampal and parahippocampal volumes in PSP patients.
Medial temporal structures may play a role in episodic memory impairment in PSP, suggesting that amnesia in PSP is not solely due to executive dysfunction.
进行性核上性麻痹（PSP）可能会出现情节记忆障碍。然而，尚不确定这是由于执行功能障碍还是负责记忆的大脑区域的参与所致。
探究 PSP 患者情节记忆障碍的特定脑区。
21 例 PSP 患者和 20 名健康对照者接受了简短认知筛查量表中的图形记忆测验（FMT）和脑 MRI 检查。我们在 PSP 患者中，调整了额叶评估量表的年龄和表现后，探讨了灰质体积和记忆评分之间的相关性。
PSP 患者在 FMT 的延迟回忆中表现差于对照组（p<0.001）。PSP 患者的延迟回忆评分与双侧海马和海马旁回体积相关。
内侧颞叶结构可能在 PSP 的情节记忆障碍中起作用，这表明 PSP 的遗忘不仅仅是由于执行功能障碍。
