Collegium Medicum, Jan Kochanowski University of Kielce, Kielce, Poland.
Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Mediators Inflamm. 2022 May 19;2022:5618867. doi: 10.1155/2022/5618867. eCollection 2022.
Sudden cardiac death (SCD) is the single major cause of death in hemodialysis (HD) patients. QRS-T angle is an established marker of global repolarization heterogeneity associated with electrical instability and SCD. Heat shock protein 27 (HSP27) plays an important, protective role against noxious factors in the cardiovascular (CV) system. This study is aimed at assessing whether low HSP27 is associated with myocardial inhomogeneities in HD patients, as expressed by increases in the spatial QRS-T angle.
Clinical data and biochemical, echocardiographic, and electrocardiographic parameters were evaluated in 182 HD patients. Patients were split into normal and abnormal QRS-T angle groups.
Patients with abnormally high QRS-T angles were older and had higher prevalence of diabetes as well as myocardial infarction, higher left ventricular mass index (LVMI) and C-reactive protein, worse oxidant/antioxidant status, and lower ejection fraction and HSP27. Multiple regression analysis revealed that abnormal QRS-T values were independently, negatively associated with serum HSP27 and positively associated with LVMI.
Low HSP27 levels are associated with increased heterogeneity of myocardial action potential, as expressed by increased spatial QRS-T angle.
心脏性猝死（SCD）是血液透析（HD）患者死亡的主要原因。QRS-T 角是与电不稳定性和 SCD 相关的整体复极异质性的既定标志物。热休克蛋白 27（HSP27）在心血管（CV）系统中对有害因素发挥着重要的保护作用。本研究旨在评估 HSP27 水平低是否与 HD 患者心肌异质性有关，如空间 QRS-T 角增加所表达的那样。
评估了 182 名 HD 患者的临床数据以及生化、超声心动图和心电图参数。患者被分为 QRS-T 角正常和异常组。
QRS-T 角异常高的患者年龄较大，糖尿病和心肌梗死的患病率更高，左心室质量指数（LVMI）和 C 反应蛋白更高，氧化/抗氧化状态更差，射血分数和 HSP27 更低。多元回归分析显示，异常 QRS-T 值与血清 HSP27 呈负相关，与 LVMI 呈正相关。
低 HSP27 水平与心肌动作电位异质性增加有关，表现为空间 QRS-T 角增加。
