Huang Min Hui, Doyle Lisa, Burnham Alexander, Fry Donna K, Shea Keelin
Physical Therapy Department, College of Health Sciences, University of Michigan-Flint, Flint, MI, USA.
Doctor of Physical Therapy Program, Franklin Pierce University, Manchester, NH, USA.
Mult Scler J Exp Transl Clin. 2022 May 23;8(2):20552173211058862. doi: 10.1177/20552173211058862. eCollection 2022 Apr-Jun.
Inspiratory muscle training (IMT) using a threshold device improves inspiratory muscle strength. What factors influence the IMT outcome has not been examined.
To identify predictors of the positive outcome following IMT in persons with advanced multiple sclerosis (PwAMS).
Inclusion criteria were non-ambulatory PwAMS, Expanded Disability Status Scale (EDSS) ≥6.5, age >18 years, no acute medical conditions, current non-smokers, and ability to consent. Participants ( = 38) performed daily inspiratory exercises using a resistive threshold device for 10 weeks. Baseline measurements included age, sex, body mass index, year post multiple sclerosis diagnosis, comorbidities, EDSS, Modified Fatigue Impact Scale-5, and oral Symbol Digit Modality Test. The percentage of completed prescribed exercise trials (Trials%) during the 10-week intervention was calculated. Age- and sex-adjusted predicted values of maximum inspiratory pressure (MIP%pred) and maximum expiratory pressure (MEP%pred) were obtained before and after the 10-week intervention. Backward multivariable regression analyses for the primary outcome (MIP%pred) were conducted.
After controlling for the initial MIP%pred, perceived fatigue at the baseline and Trial% were significant and independent predictors of MIP%pred after IMT.
Less fatigue at the baseline and higher adherence to the prescribed exercise repetitions were positive predictors of the positive outcome following IMT in PwAMS.
使用阈值装置进行吸气肌训练（IMT）可提高吸气肌力量。尚未研究哪些因素会影响IMT的效果。
确定晚期多发性硬化症患者（PwAMS）IMT后阳性结果的预测因素。
纳入标准为非卧床PwAMS、扩展残疾状态量表（EDSS）≥6.5、年龄>18岁、无急性疾病、当前不吸烟且有同意能力。参与者（n = 38）使用阻力阈值装置进行每日吸气锻炼，持续10周。基线测量包括年龄、性别、体重指数、多发性硬化症诊断后的年份、合并症、EDSS、改良疲劳影响量表-5和口头符号数字模态测试。计算10周干预期间完成规定运动试验的百分比（试验百分比）。在10周干预前后获得年龄和性别调整后的最大吸气压力预测值（MIP%pred）和最大呼气压力预测值（MEP%pred）。对主要结局（MIP%pred）进行向后多变量回归分析。
在控制初始MIP%pred后，基线时的感知疲劳和试验百分比是IMT后MIP%pred的显著且独立的预测因素。
基线时疲劳程度较低和对规定运动重复次数的依从性较高是PwAMS中IMT后阳性结果的阳性预测因素。
