Department of Special Examination, The First People's Hospital of Fuyang District, Hangzhou 311400, China.
Department of Pathology, The First People's Hospital of Fuyang District, Hangzhou 311400, China.
Comput Intell Neurosci. 2022 May 20;2022:9281636. doi: 10.1155/2022/9281636. eCollection 2022.
To analyze the diagnostic value of serum growth differentiation factor 15 (GDFl5) and high-sensitivity troponin T (hs-cTnT) in elderly acute myocardial infarction (AMI).
A retrospective analysis of 165 patients with acute chest pain admitted to the Department of Cardiology in our hospital from January to December 2020, Among them, 76 AMI patients (AMI group), 89 non-AMI patients (non-AMI group), and 80 healthy people were selected as the control group during the same period. Compare the three groups of serum GDF15, hs-CTnT levels, and left ventricular ejection fraction (LVEF) parallel correlation analysis, and draw the receiver operating curve (ROC) of serum GDF15 and hs-CTnT levels to diagnose AMI.
The serum GDF15 and hs-CTnT levels of the AMI group were significantly higher than those of the non-AMI group and the control group, and the difference was statistically significant ( < 0.01). The LVEF was significantly lower than the non-AMI group and the control group, whose difference was statistically significant ( < 0.01). Among them, the indicators of the non-AMI group were both higher and lower than the control group, and the difference was statistically significant ( < 0.01). Serum GDF15 and hs-CTnT levels of AMI patients increased with the increase of NYHA grade, among which grade IV group was significantly higher than grade I∼II group and grade III group ( < 0.01), and grade III group was significantly higher than grade I∼II Group ( < 0.01). Pearson correlation analysis showed that GDF15 and hs-CTnT levels of AMI patients were significantly negatively correlated with LVEF ( = -0.584, -0.612, - < 0.01). The ROC curve showed that GDF15 had a high specificity (93.75%) and hs-CTnT has a high sensitivity (90.67%). The area under the curve for diagnosing AMI is > 0.7 (0.895, 0.948). The sensitivity of the combined detection and the specificity are higher than that of individual detection.
Serum GDF15 and hs-CTnT are highly expressed in elderly patients with AMI. The combined detection of the two can improve the efficiency of AMI diagnosis. GDF15 can be used as a new biomarker for AMI diagnosis and disease monitoring.
分析血清生长分化因子 15（GDF15）和高敏肌钙蛋白 T（hs-cTnT）在老年急性心肌梗死（AMI）中的诊断价值。
回顾性分析 2020 年 1 月至 12 月我院心内科收治的 165 例胸痛急性患者，其中 AMI 患者 76 例（AMI 组），非 AMI 患者 89 例（非 AMI 组），同期健康体检者 80 例作为对照组。比较三组血清 GDF15、hs-CTnT 水平及左心室射血分数（LVEF）并行相关性分析，绘制血清 GDF15、hs-CTnT 水平的受试者工作特征曲线（ROC）诊断 AMI。
AMI 组血清 GDF15、hs-CTnT 水平明显高于非 AMI 组和对照组，差异有统计学意义（ < 0.01）。LVEF 明显低于非 AMI 组和对照组，差异有统计学意义（ < 0.01）。其中，非 AMI 组的指标均高于对照组，差异有统计学意义（ < 0.01）。AMI 患者血清 GDF15、hs-CTnT 水平随 NYHA 分级增加而升高，其中Ⅳ级组明显高于Ⅰ∼Ⅱ级组和Ⅲ级组（ < 0.01），Ⅲ级组明显高于Ⅰ∼Ⅱ级组（ < 0.01）。Pearson 相关性分析显示，AMI 患者 GDF15、hs-CTnT 水平与 LVEF 呈明显负相关（ = -0.584、-0.612、- < 0.01）。ROC 曲线显示，GDF15 具有较高的特异性（93.75%），hs-CTnT 具有较高的敏感性（90.67%）。诊断 AMI 的曲线下面积均 > 0.7（0.895、0.948）。联合检测的灵敏度和特异性均高于单项检测。
老年 AMI 患者血清 GDF15、hs-CTnT 表达水平升高，两者联合检测可提高 AMI 诊断效率。GDF15 可作为 AMI 诊断和疾病监测的新标志物。
