Kinzler K W, Bigner S H, Bigner D D, Trent J M, Law M L, O'Brien S J, Wong A J, Vogelstein B
Science. 1987 Apr 3;236(4797):70-3. doi: 10.1126/science.3563490.
A gene, termed gli, was identified that is amplified more than 50-fold in a malignant glioma. The gene is expressed at high levels in the original tumor and its derived cell line and is located at chromosome 12 position (q13 to q14.3). The gli gene is a member of a select group of cellular genes that are genetically altered in primary human tumors.
一个名为gli的基因在恶性胶质瘤中扩增了50倍以上。该基因在原发肿瘤及其衍生的细胞系中高表达，位于12号染色体（q13至q14.3）。gli基因是在原发性人类肿瘤中发生基因改变的一组特定细胞基因的成员。
