Low Ann-Marie, Vangkilde Signe, le Sommer Julijana, Fagerlund Birgitte, Glenthøj Birte, Jepsen Jens Richardt Møllegaard, Habekost Thomas
Department of Psychology, University of Copenhagen, Copenhagen, Denmark.
Center for Neuropsychiatric Schizophrenia Research (CNSR) and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), University of Copenhagen, Copenhagen, Denmark.
Nord J Psychiatry. 2023 Jan;77(1):102-107. doi: 10.1080/08039488.2022.2080253. Epub 2022 May 28.
Methylphenidate is a first-line treatment for ADHD; its contribution to sleep problems in adult ADHD is currently unclear. This study investigates (a) subjective sleep disturbances in a group of initially stimulant medication-naïve adults with ADHD and (b) reported changes in sleep problems after 6 weeks of methylphenidate treatment.
A prospective, non-randomized, non-blinded, 6-week follow-up study utilising a self-report measure.
We found (1) a large difference in reported sleep quality between methylphenidate medication-naïve patients and controls at baseline, (2) a marked improvement in patients after methylphenidate medication, and (3) largest improvement for patients with the poorest reported sleep at baseline.
The study indicates that treatment with methylphenidate increases subjective sleep quality for at least some adults with ADHD.
哌甲酯是治疗注意力缺陷多动障碍（ADHD）的一线药物；目前尚不清楚其对成人ADHD睡眠问题的影响。本研究调查了（a）一组初始未服用兴奋剂药物的成人ADHD患者的主观睡眠障碍，以及（b）哌甲酯治疗6周后报告的睡眠问题变化。
一项前瞻性、非随机、非盲法的6周随访研究，采用自我报告测量方法。
我们发现（1）在基线时，未服用哌甲酯药物的患者与对照组报告的睡眠质量存在很大差异，（2）患者在服用哌甲酯药物后有显著改善，（3）基线时报告睡眠最差的患者改善最大。
该研究表明，哌甲酯治疗至少能提高部分成人ADHD患者的主观睡眠质量。
