Cell and Molecular Biology Lab, Department of Zoology, Panjab University, Chandigarh, 160014, India.
J Mol Neurosci. 2022 Jun;72(6):1259-1273. doi: 10.1007/s12031-022-02033-7. Epub 2022 May 30.
Valproic acid (VPA) induced rodent model of autism is a widely accepted and extensively used rodent model to investigate the pharmacotherapy against autism. But, to date, its validation, suitability, and applicability as a well defining autistic model are still questionable. Previous research efforts highlighted that this model shows various core defining features of autism and related pathways, hence it is very necessary to explore its authenticity as a well-suited model for autism. Therefore, in this review, we summarize the preclinical and neurobiological relevant validated features, involved etiological mechanism, biological markers, treatment responses, drawbacks, current approaches, and future perspectives of VPA-induced model of autism. This review would help in deciphering the validation of the VPA-induced autistic model and its suitability as an experimental model of autism. A thorough investigation of behavioral, molecular, and neurobiological processes in animal models of autism would help in investigating the exact causation and effective treatment for autism.
丙戊酸（VPA）诱导的自闭症啮齿动物模型是一种被广泛接受和广泛应用于自闭症药物治疗研究的啮齿动物模型。但是，迄今为止，其验证、适用性和作为一种明确的自闭症模型的适用性仍存在疑问。先前的研究工作强调，该模型显示出自闭症和相关途径的各种核心定义特征，因此非常有必要探索其作为自闭症模型的真实性。因此，在这篇综述中，我们总结了丙戊酸诱导自闭症模型的临床前和神经生物学相关的验证特征、涉及的发病机制、生物标志物、治疗反应、缺点、当前方法和未来展望。这篇综述将有助于阐明 VPA 诱导自闭症模型的验证及其作为自闭症实验模型的适用性。对自闭症动物模型的行为、分子和神经生物学过程进行彻底研究，将有助于研究自闭症的确切病因和有效治疗方法。
