Department of Cardiology, Adıyaman University Training and Research Hospital, Adıyaman, Turkey.
Ann Noninvasive Electrocardiol. 2022 Jul;27(4):e12970. doi: 10.1111/anec.12970. Epub 2022 May 30.
Coronary artery disease (CAD) is one of the important causes of mortality. It has been emphasized that the risk of CAD may be increased in the relatives of CAD patients. Fragmented QRS (fQRS) is an electrocardiography (ECG) marker showing myocardial damage.
A study group of 62 symptomatic individuals (31 males, mean age 38.5 ± 7.12 years) with first-degree relatives with coronary artery disease and 64 healthy volunteers (24 males, mean age 37.9 ± 11.6 years) were included in this study. The study did not include those with known cardiac disease, metabolic disease, or drug use that may cause a change in ECG parameters.
There was no significant difference between the groups regarding gender, heart rate, QRS complex, QTc, frontal QRS-T angle, and left ventricle ejection fraction. Compared to the control group, the QT interval and fQRS count were significantly higher in the study group (p < .05 for both). Low-density lipoprotein cholesterol (LDL-C), hemoglobin, and neutrophil counts were significantly higher in the study group compared to the control group (p < .05 for all).
Our study showed that fQRS was increased in individuals with symptomatic first-degree relatives with coronary artery disease compared to healthy volunteers.
冠心病（CAD）是导致死亡的重要原因之一。已强调 CAD 患者的亲属发生 CAD 的风险可能会增加。碎裂 QRS 波（fQRS）是一种心电图（ECG）标志物，显示心肌损伤。
本研究纳入了 62 名有症状的个体（31 名男性，平均年龄 38.5±7.12 岁），这些个体的一级亲属患有冠心病，以及 64 名健康志愿者（24 名男性，平均年龄 37.9±11.6 岁）。本研究不包括已知有心脏病、代谢疾病或可能改变 ECG 参数的药物使用史的患者。
两组间的性别、心率、QRS 复合体、QTc、额面 QRS-T 角和左心室射血分数无显著差异。与对照组相比，研究组的 QT 间期和 fQRS 计数显著更高（均 p<.05）。与对照组相比，研究组的低密度脂蛋白胆固醇（LDL-C）、血红蛋白和中性粒细胞计数显著更高（均 p<.05）。
我们的研究表明，与健康志愿者相比，有症状的一级亲属患有冠心病的个体 fQRS 增加。
