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开放式与封闭式硬膜外导管设计在不同程控间歇硬膜外输注速率下对注药压力和染剂扩散的影响:一项体外研究。

The effect of open-end versus closed-end epidural catheter design on injection pressure and dye diffusion under various programmed intermittent epidural delivery rates: an in vitro study.

机构信息

Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.

Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.

出版信息

Int J Obstet Anesth. 2022 Aug;51:103252. doi: 10.1016/j.ijoa.2022.103252. Epub 2022 Jan 12.

Abstract

BACKGROUND

Epidural catheter design may impact injection pressure and analgesic outcomes under programmed intermittent epidural bolus regimens. This in vitro study aimed to compare the injection pressure and dye diffusion between open-end and closed-end catheters at varying delivery rates.

METHODS

The injection pressure and dye diffusion distance and area were measured at five delivery rates (120, 240, 360, 480, and 600 mL/h) through three epidural catheters (OE-3, open-end, three lateral ports; CE-3, closed-end, three lateral ports; OE-0, open-end, single port). A two-way analysis of variance with the Bonferroni post hoc test was applied for comparisons between the catheter groups and delivery rates.

RESULTS

Forty-five pressure tests and 45 dye diffusion measurements were performed. The peak pressure was significantly higher with the closed-end catheter at 240, 360, 480, and 600 mL/h delivery rates (P<0.025). The diffusion distance was shorter at all delivery rates (P<0.001). At 360 mL/h, the diffusion area was larger with CE-3 than with OE-0 catheters, but at 600 mL/h it was smaller with CE-3 than with OE-3 catheters (CE-3 vs. OE-0 at 360 mL/h, P<0.025; CE-3 vs. OE-3 at 600 mL/h, P<0.025).

CONCLUSIONS

At high delivery rates (>360 mL/h), the closed-end catheter had no advantages over the open-end catheters in diffusion distance or area. When using a close-ended catheter and high delivery rates, the peak pressure generated might trigger the occlusion alarm.

摘要

背景

硬膜外导管的设计可能会影响程控间歇硬膜外推注方案下的注射压力和镇痛效果。本体外研究旨在比较不同流速下,开口式和密闭式导管的注射压力和染料扩散情况。

方法

通过三种硬膜外导管(OE-3,开口式,三个侧口;CE-3,密闭式,三个侧口;OE-0,开口式,单口)在五个流速(120、240、360、480 和 600mL/h)下测量注射压力和染料扩散距离和面积。采用双向方差分析和 Bonferroni 事后检验比较导管组和流速之间的差异。

结果

进行了 45 次压力测试和 45 次染料扩散测量。在 240、360、480 和 600mL/h 的流速下,密闭式导管的峰值压力显著更高(P<0.025)。在所有流速下,扩散距离都更短(P<0.001)。在 360mL/h 时,CE-3 导管的扩散面积大于 OE-0 导管,但在 600mL/h 时,CE-3 导管的扩散面积小于 OE-3 导管(CE-3 与 OE-0 在 360mL/h 时,P<0.025;CE-3 与 OE-3 在 600mL/h 时,P<0.025)。

结论

在高流速(>360mL/h)下,密闭式导管在扩散距离或面积方面并不优于开口式导管。当使用密闭式导管和高流速时,产生的峰值压力可能会触发阻塞报警。

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