一种自压力驱动的用于即时诊断的血浆分离装置。
A self-pressure-driven blood plasma-separation device for point-of-care diagnostics.
机构信息
Biomedical Engineering Research Center, Smart Healthcare Research Institute, Samsung Medical Center, Seoul, South Korea; Department of Medical Device Management and Research, SAIHST (Samsung Advanced Institute for Health Sciences & Technology), Sungkyunkwan University, Seoul, South Korea.
Biomedical Engineering Research Center, Smart Healthcare Research Institute, Samsung Medical Center, Seoul, South Korea.
出版信息
Talanta. 2022 Sep 1;247:123562. doi: 10.1016/j.talanta.2022.123562. Epub 2022 May 17.
We aimed to develop a portable, simple-to-use, and self-pressure-driven blood plasma-separation device that can be combined with rapid diagnostic test kits. This simple, disposable, and electrical equipment-free apparatus has been designed to separate plasma from a few microliters of blood with only hand-powered operation. The refined plasma sample is then delivered to multiple lateral flow assay kits directly connected to the device for the detection of various serological markers. The required time for all steps was just 1 min. We validated the device through multifaceted experiments. The developed multifunctional device enables to perform all blood test steps of diagnostic medical examination at the point-of-care.
我们旨在开发一种便携式、易于使用且可自行加压的血浆分离设备，该设备可与快速诊断试剂盒结合使用。这个简单、一次性且无需电器设备的仪器，通过手动操作即可从几微升血液中分离出血浆。然后，精制的血浆样本被输送到与该设备直接相连的多个侧向流动分析试剂盒中，以检测各种血清标志物。所有步骤所需的时间仅为 1 分钟。我们通过多方面的实验验证了该设备。所开发的多功能设备可实现在医疗点进行诊断性医疗检查的所有血液检测步骤。
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