Department of Urology, Wake Forest School of Medicine, Winston-Salem, NC; Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC.
Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC.
Urology. 2022 Sep;167:96-101. doi: 10.1016/j.urology.2022.05.021. Epub 2022 May 28.
To evaluate the efficacy of pulsed electromagnetic field (PEMF) therapy for symptom and pain management in women with non-bladder centric interstitial cystitis/bladder pain syndrome (IC/BPS).
Women with non-bladder centric IC/BPS and a numeric rating scale score for pelvic pain ≥6 underwent twice-daily 8-minute full body PEMF therapy sessions for 4 weeks. The primary outcome metric was a reduction in pelvic pain score ≥2 points. A 7-day voiding diary (collected at baseline and conclusion), 3 validated symptom scores, and the Short Form-36 Quality of Life questionnaire (completed at baseline, conclusion of treatment, and 8-week follow-up), were used to assess secondary outcomes. Treatment effects were analyzed via Wilcoxon-signed rank test; P < .05 was considered significant.
The 4-week treatment protocol was completed by 8 of 10 enrolled patients, and 7:8 (87.5%) had a significant reduction in pelvic pain (-3.0 points, P = .011) after 4 weeks. There was also a significant decrease in scores on all validated IC/BPS questionnaires, daily number of voids, and nocturia symptom score (P < .05). Significant increases in several quality-of-life questionnaire sub-scores were also identified at 4 weeks (P < .05). At 8-week post-therapy, the positive effects were somewhat attenuated, yet 4:8 patients (50%) continued to have significant pain reduction (P = .047). No adverse events or side effects were reported.
Whole body pulsed electromagnetic field therapy is an alternative treatment option for women with chronic bladder pain syndrome that warrants investigation through comparative trials.
评估脉冲电磁场（PEMF）治疗对非膀胱中心型间质性膀胱炎/膀胱疼痛综合征（IC/BPS）女性症状和疼痛管理的疗效。
对患有非膀胱中心型 IC/BPS 且盆腔疼痛数字评分量表（NRS）评分≥6 的女性进行每日两次、每次 8 分钟的全身 PEMF 治疗，共 4 周。主要结局指标为盆腔疼痛评分降低≥2 分。采用 7 天排尿日记（基线和结论时收集）、3 种经过验证的症状评分和简明健康状况调查问卷 36 项简表（基线、治疗结束时和 8 周随访时完成）来评估次要结局。采用 Wilcoxon 符号秩检验分析治疗效果；P<.05 为差异有统计学意义。
10 名入组患者中有 8 名完成了 4 周的治疗方案，7 名患者（87.5%）在 4 周后盆腔疼痛显著减轻（-3.0 分，P=.011）。所有经过验证的 IC/BPS 问卷、每日排尿次数和夜尿症状评分也显著降低（P<.05）。几个生活质量问卷子量表的评分在 4 周时也显著增加（P<.05）。在治疗后 8 周，积极效果有所减弱，但仍有 4 名患者（50%）继续显著减轻疼痛（P=.047）。无不良事件或副作用报告。
全身脉冲电磁场治疗是一种治疗慢性膀胱疼痛综合征的替代治疗选择，值得通过对照试验进行研究。
