腹部肥胖、慢性炎症与非酒精性脂肪性肝病风险。

Abdominal obesity, chronic inflammation and the risk of non-alcoholic fatty liver disease.

机构信息

Operating Theatre, Kailuan General Hospital, Tangshan, China.

School of Medicine, Nankai University, Tianjin, China; Department of Hepatobiliary surgery, Kailuan General Hospital, Tangshan 0063000, China.

出版信息

Ann Hepatol. 2023 Jul-Aug;28(4):100726. doi: 10.1016/j.aohep.2022.100726. Epub 2022 May 27.

DOI:10.1016/j.aohep.2022.100726

PMID:35636732

Abstract

INTRODUCTION AND OBJECTIVES

The purpose of this study was to evaluate the effect of abdominal obesity and chronic inflammation on risk of non-alcoholic fatty liver disease (NAFLD) among Chinese population.

MATERIALS AND METHODS

Overall, 50776 staff from the Kailuan Group who participated in and finished physical examinations between 2006 and 2007 were included in the cohort study. Their medical information was collected and they were followed after examination. The correlations of waist-to-height ratio (WHtR) or serum high-sensitivity C-reactive protein (hs-crp) with NAFLD were analyzed. Then, we categorized all participants into four groups: non-abdominal obesity and non-chronic inflammation group, abdominal obesity and non-chronic inflammation group, non-abdominal obesity and chronic inflammation group, abdominal obesity and chronic inflammation group, and non-abdominal obesity and non-chronic inflammation group was used as a control group. The combined effects of abdominal obesity and chronic inflammation with NAFLD were analyzed using the Cox proportional hazard regression model.

RESULTS

After a mean follow-up of 5.59±1.79 years, a total of 15451 NAFLD cases occurred. We found the WHtR and hs-crp increase the risk for NAFLD, respectively. Compared with the non-abdominal obesity and non-chronic inflammation group, the risk of NAFLD was significantly increased in the abdominal obesity and non-chronic inflammation group (HR 1.21, 95%CI 1.11-1.32), non-abdominal obesity and chronic inflammation group (HR 1.32, 95%CI 1.27-1.38), abdominal obesity and chronic inflammation group (HR 1.60, 95% CI 1.52-1.70). And, a significant interaction effect was found of abdominal obesity and chronic inflammation on NAFLD.

CONCLUSIONS

In this study, it was demonstrated in the Chinese population that both abdominal obesity and chronic inflammation increase the risk of NAFLD, and there is an interaction between the two factors in the incidence of NAFLD.

摘要

简介和目的

本研究旨在评估中国人群中腹型肥胖和慢性炎症对非酒精性脂肪性肝病（NAFLD）风险的影响。

材料和方法

本队列研究纳入了 2006 年至 2007 年间参加并完成体检的开滦集团 50776 名员工。收集他们的医疗信息，并在检查后进行随访。分析腰围身高比（WHtR）或血清高敏 C 反应蛋白（hs-crp）与 NAFLD 的相关性。然后，我们将所有参与者分为四组：非腹型肥胖且无慢性炎症组、腹型肥胖且无慢性炎症组、非腹型肥胖且有慢性炎症组、腹型肥胖且有慢性炎症组，以非腹型肥胖且无慢性炎症组作为对照组。采用 Cox 比例风险回归模型分析腹型肥胖和慢性炎症与 NAFLD 的联合作用。

结果

经过平均 5.59±1.79 年的随访，共发生 15451 例 NAFLD 病例。我们发现 WHtR 和 hs-crp 分别增加了 NAFLD 的风险。与非腹型肥胖且无慢性炎症组相比，腹型肥胖且无慢性炎症组（HR 1.21，95%CI 1.11-1.32）、非腹型肥胖且有慢性炎症组（HR 1.32，95%CI 1.27-1.38）、腹型肥胖且有慢性炎症组（HR 1.60，95%CI 1.52-1.70）的 NAFLD 发病风险显著增加。并且，腹型肥胖和慢性炎症对 NAFLD 的发生存在显著的交互作用。