Ortiz Salas P A, Gaviria Carrillo M, Cortés Bernal G A, Moreno Medina K, Roa L F, Rodríguez Quintana J H
Servicio de Neurología, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia; Universidad del Rosario, Grupo Neuros, Bogotá, Colombia.
Servicio de Neurología, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia; Universidad del Rosario, Programa de Neurología, Bogotá, Colombia.
Neurologia (Engl Ed). 2023 Sep;38(7):504-510. doi: 10.1016/j.nrleng.2020.08.022. Epub 2022 May 28.
Neuromyelitis optica (NMO) is an inflammatory disease of the central nervous system characterised by attacks of optic neuritis and longitudinally extensive transverse myelitis. The discovery of anti-aquaporin-4 (anti-AQP4) antibodies and specific brain MRI findings as diagnostic biomarkers have enabled the recognition of a broader and more detailed clinical phenotype, known as neuromyelitis optica spectrum disorder (NMOSD).
This study aimed to determine the demographic and clinical characteristics of patients with NMO/NMOSD with and without seropositivity for anti-AQP4 antibodies, in 2 quaternary-level hospitals in Bogotá.
Our study included patients > 18 years of age and diagnosed with NMO/NMOSD and for whom imaging and serology results were available, assessed between 2013 and 2017 at the neurology departments of hospitals providing highly complex care. Demographic, clinical, and imaging data were gathered and compared in patients with and without seropositivity for anti-AQP4 antibodies.
The sample included 35 patients with NMO/NMOSD; the median age of onset was 46.5 years (P25-P75, 34.2-54.0); most patients had sensory (n = 25) and motor manifestations (n = 26), and a concomitant autoimmune disease was identified in 6. Twenty patients were seropositive for anti-AQP4 antibodies. Only age and presence of optic nerve involvement showed statistically significant differences between groups (P = .03).
Clinical, imaging, and laboratory variables showed no major differences between patients with and without anti-AQP4 antibodies, with the exception of age of onset and presence of optic nerve involvement (uni- or bilateral); these factors should be studied in greater detail in larger populations.
视神经脊髓炎（NMO）是一种中枢神经系统炎性疾病，其特征为视神经炎发作和纵向广泛横贯性脊髓炎。抗水通道蛋白4（抗AQP4）抗体的发现以及特定的脑部MRI表现作为诊断生物标志物，使得人们能够识别出一种更广泛、更详细的临床表型，即视神经脊髓炎谱系障碍（NMOSD）。
本研究旨在确定波哥大两家四级医院中抗AQP4抗体血清学阳性和阴性的NMO/NMOSD患者的人口统计学和临床特征。
我们的研究纳入了年龄大于18岁、被诊断为NMO/NMOSD且有影像学和血清学结果的患者，这些患者于2013年至2017年在提供高度复杂护理的医院神经科进行了评估。收集了抗AQP4抗体血清学阳性和阴性患者的人口统计学、临床和影像学数据并进行比较。
样本包括35例NMO/NMOSD患者；发病年龄中位数为46.5岁（P25-P75，34.2-54.）；大多数患者有感觉（n=25）和运动表现（n=26），6例患者合并有自身免疫性疾病。20例患者抗AQP4抗体血清学阳性。两组之间仅年龄和视神经受累情况存在统计学显著差异（P=.03）。
临床、影像学和实验室变量在抗AQP4抗体阳性和阴性患者之间没有显示出重大差异，但发病年龄和视神经受累情况（单侧或双侧）除外；这些因素应在更大规模人群中进行更详细的研究。
