North Downs Specialist Referrals, 3 & 4 The Brewerstreet Dairy Business Park, Bletchingley, UK.
Vet Dermatol. 2022 Aug;33(4):345-e80. doi: 10.1111/vde.13079. Epub 2022 May 30.
Epitheliotropic lymphoma is an uncommon cutaneous malignancy of T lymphocytes. Limited information is available regarding the treatment and outcome of dogs with this disease.
To evaluate the treatment outcome and toxicity profile of isotretinoin in dogs with epitheliotropic lymphoma.
Twelve dogs with a diagnosis of epitheliotropic lymphoma were included.
A medical database was searched for dogs diagnosed with epitheliotropic lymphoma and treated with isotretinoin between 2010 and 2021. Diagnosis, treatment details and tumour response were recorded for 12 dogs.
All lesions resolved in four of 12 (33%) treated dogs. Lesions visibly improved in a further three dogs, giving a response rate of 58%. Two dogs' lesions remained unchanged and three progressed despite therapy. Adverse effects occurred in three dogs (25%), all of which were rapidly resolving or not affecting quality of life.
Isotretinoin treatment was a well-tolerated and effective treatment for canine epitheliotropic lymphoma.
亲上皮性淋巴瘤是一种罕见的 T 淋巴细胞皮肤恶性肿瘤。关于这种疾病的治疗和结果的信息有限。
评估异维 A 酸治疗亲上皮性淋巴瘤犬的治疗效果和毒性特征。
纳入了 12 只诊断为亲上皮性淋巴瘤的犬。
检索了 2010 年至 2021 年间接受异维 A 酸治疗的患有亲上皮性淋巴瘤的犬的医学数据库。记录了 12 只犬的诊断、治疗细节和肿瘤反应。
在 12 只接受治疗的犬中，有 4 只（33%）的所有病变完全消退。另有 3 只犬的病变明显改善，反应率为 58%。2 只犬的病变没有变化，3 只犬的病变尽管进行了治疗仍在进展。3 只犬（25%）出现了不良反应，所有不良反应都在迅速缓解或未影响生活质量。
异维 A 酸治疗是一种耐受良好且有效的犬亲上皮性淋巴瘤治疗方法。
