通过海藻糖二硬脂酸酯缀合靶向 Mincle 的合成疫苗。
Synthetic vaccines targeting Mincle through conjugation of trehalose dibehenate.
机构信息
School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, School of Chemistry, The University of Sydney, NSW 2006, Australia.
出版信息
Chem Commun (Camb). 2022 Jun 16;58(49):6890-6893. doi: 10.1039/d2cc02100e.
The covalent fusion of immunostimulatory adjuvants to immunogenic antigens is a promising strategy for the development of effective synthetic vaccines for infectious diseases. Herein, we describe the conjugation of a mycobacterial peptide antigen from the 6 kDa early secretory antigenic target (ESAT6) to a suitably functionalised trehalose dibehenate (TDB), a potent glycolipid adjuvant targeting macrophage inducible C-type lectin (Mincle).
将免疫刺激性佐剂共价融合到免疫原性抗原上是开发用于传染病的有效合成疫苗的一种很有前途的策略。在此，我们描述了分枝杆菌肽抗原 6 kDa 早期分泌抗原靶标（ESAT6）与适当功能化海藻糖二硬脂酸酯（TDB）的缀合，TDB 是一种靶向巨噬细胞诱导 C 型凝集素（Mincle）的有效糖脂佐剂。
Zotero 插件