Department of Gynecology, Cancer Hospital of China Medical University, Dadong District, Shenyang, Liaoning Province, People's Republic of China.
Department of Gynecology, Liaoning Cancer Hospital & Institute, Dadong District, Shenyang, Liaoning Province, People's Republic of China.
Carcinogenesis. 2022 Aug 30;43(7):635-646. doi: 10.1093/carcin/bgac048.
Aberrant gene methylation has been implicated in the development and progression of tumors. In this study, we aimed to identity methylation-driven genes involved in epithelial ovarian cancer (EOC) to establish a prognostic signature for patients with EOC. We identified and verified 6 MDGs that are closely related to the prognosis of ovarian cancer. A prognostic risk score model and nomogram for predicting the prognosis of ovarian cancer were constructed based on the six MDGs. It can also effectively reflect the immune environment and immunotherapy response of ovarian cancer. These MDGs have great significance to the implementation of individualized treatment and disease monitoring of ovarian cancer patients.
异常基因甲基化与肿瘤的发生和发展有关。在这项研究中，我们旨在确定参与卵巢上皮性癌（EOC）的甲基化驱动基因，为 EOC 患者建立预后标志物。我们鉴定并验证了 6 个与卵巢癌预后密切相关的 MDGs。基于这 6 个 MDGs，构建了预测卵巢癌预后的风险评分模型和列线图。它还可以有效地反映卵巢癌的免疫环境和免疫治疗反应。这些 MDGs 对实施卵巢癌患者的个体化治疗和疾病监测具有重要意义。
