Department of Congenital Heart Disease, Evelina London Children's Hospital, London, UK.
Eur J Cardiothorac Surg. 2022 Jul 11;62(2). doi: 10.1093/ejcts/ezac324.
There is increasing evidence that performing superior cavopulmonary connection (SCPC) at 3 months reduces mortality: reducing the risky 'interstage' period, volume off-loading the ventricle and reducing coronary steal, hopefully preserving ventricular function. Our objective was to describe our experience of early SCPC with preoperative computer tomography (CT) assessment compared to later connection at 6 months.
Patients undergoing Norwood procedure from 2005 to 2020 were divided into 2 eras were described and compared. Era 1 from 2005 to 2016 when SCPC was undertaken at 6 months: and era 2 (2017-2020) when an earlier operation was performed. Demographics, mortality (interstage, early and late following SCPC) and data on postoperative course and complications were recorded.
In era 1, 191 patients underwent Norwood (120 survivors to SCPC) and 28 patients (23 survivors) in era 2. There were no significant differences in the demographics. Interstage mortality was 17.8% in era 1 and 8.0% in era 2 but not significantly significant (P = 0.22). The median (interquartile range) age at pre-imaging and SCPC was significantly lower: 99 (81-120) vs 77 (47-102) days and 175 (117-208) vs 106 (102-122) days in era 1 vs era 2 (P < 0.005). Weight was lower at SCPC in era 2 [mean (standard deviation) 6.2 kg (1.2) vs 5.1 kg (0.8), P < 0.05]. Intubation time and total length of stay were not statistically different. Median intensive care unit stay was statistically significantly longer, but not clinically significant: 2.5 (2-4) vs 3 (3-5) days, respectively (P < 0.05). There was no significant difference in early or late mortality, rates of diagnostic or interventional catheter, postoperative magnetic resonance imaging/CT or stroke. Logistic regression analysis demonstrates increasing age at SCPC was associated with increased chance of stroke or early death (P = 0.043).
Early SCPC with CT assessment is feasible and although intensive care unit length of stay was slightly longer there was no change in the overall length of stay and no change in postoperative mortality or complications.
越来越多的证据表明,在 3 个月时进行优秀的腔静脉-肺动脉吻合术(SCPC)可降低死亡率:减少危险的“中间期”,减轻心室的容量负担,减少冠状动脉窃血,从而有望保留心室功能。我们的目的是描述我们在术前计算机断层扫描(CT)评估的情况下进行早期 SCPC 的经验,并与 6 个月时的后期吻合术进行比较。
将 2005 年至 2020 年间接受 Norwood 手术的患者分为两个时期进行描述和比较。时期 1(2005 年至 2016 年)时,SCPC 在 6 个月时进行;时期 2(2017-2020 年)时,进行早期手术。记录患者的人口统计学特征、死亡率(中间期、SCPC 早期和晚期)以及术后过程和并发症的数据。
时期 1 中,191 例患者接受了 Norwood 手术(120 例存活至 SCPC),28 例患者(23 例存活)在时期 2 中接受了手术。两组患者的人口统计学特征无显著差异。时期 1 中,中间期死亡率为 17.8%,时期 2 中为 8.0%,但无统计学显著差异(P=0.22)。时期 1 中,进行术前成像和 SCPC 的中位(四分位距)年龄明显较低:99(81-120)天 vs 77(47-102)天,175(117-208)天 vs 106(102-122)天;时期 2(P<0.005)。SCPC 时,时期 2 的体重较低[平均(标准差)6.2kg(1.2)vs 5.1kg(0.8),P<0.05]。插管时间和总住院时间无统计学差异。重症监护病房的中位住院时间有统计学意义,但无临床意义:分别为 2.5(2-4)天和 3(3-5)天(P<0.05)。早期或晚期死亡率、诊断或介入导管率、术后磁共振成像/CT 或中风率无显著差异。Logistic 回归分析表明,SCPC 时年龄的增加与中风或早期死亡的几率增加有关(P=0.043)。
进行 CT 评估的早期 SCPC 是可行的,尽管重症监护病房的住院时间略长,但总住院时间和术后死亡率或并发症没有变化。