el-Asmar M F, Shaban E, Hagag M, Swelam N, Tu A
Toxicon. 1986;24(11-12):1037-44. doi: 10.1016/0041-0101(86)90130-3.
A coagulant component has been purified from Cerastes cerastes venom, using gel filtration on a Sephadex G 100 (fine) column followed by chromatography on a Bio-Rex 70 column. This compound had a proteolytic effect and could coagulate human plasma deficient in factor VIII or (VIII + IX) with the formation of a firm clot. It could also clot plasma deficient in factor X, but the clot formed was soft and not complete. The compound had no effect on platelet aggregation and was nontoxic. This compound is believed to be primarily a factor X activator, as it could replace factor VIII in hemophilic plasmas.
已从角蝰蛇毒液中纯化出一种凝血成分，方法是先在葡聚糖G 100（细）柱上进行凝胶过滤，然后在Bio-Rex 70柱上进行色谱分析。该化合物具有蛋白水解作用，能使缺乏因子VIII或（VIII + IX）的人血浆凝固，形成坚实的凝块。它也能使缺乏因子X的血浆凝固，但形成的凝块柔软且不完全。该化合物对血小板聚集没有影响且无毒。这种化合物被认为主要是一种因子X激活剂，因为它可以替代血友病血浆中的因子VIII。
