Sorbonne Université, AP-HP, Hôpitaux Universitaires Pitié-Salpêtrière Charles Foix, Service de Maladies infectieuses et Tropicales, 75013, Paris, France.
Sorbonne Université, AP-HP, Hôpitaux Universitaires Pitié-Salpêtrière Charles Foix, Service de Parasitologie-Mycologie, 75013, Paris, France.
Int J Infect Dis. 2022 Sep;122:244-251. doi: 10.1016/j.ijid.2022.05.056. Epub 2022 May 28.
Invasive aspergillosis is a threat for immunocompromised patients. We present a case series of aggressive cerebral vasculitis caused by Aspergillus spp. infection in immunocompromised patients.
We present a retrospective case series of three autopsy-proven invasive cerebral aspergillosis with diffuse vasculitis affecting large caliber cerebral vessels.
Three patients were immunosuppressed: one on rituximab, one on corticosteroids, and one with a renal transplant. Two of these patients were diagnosed with cerebral aspergillosis on postmortem.
Aspergillus cerebral vasculitis is a rare form of invasive aspergillosis that should be considered in an immunocompromised individual with suggestive lesions on imaging. It should be suspected as a possible cause of aseptic neutrophil meningitis.
侵袭性曲霉病是免疫功能低下患者的威胁。我们报告了三例由曲霉菌属感染引起的免疫功能低下患者侵袭性脑血管炎的病例系列。
我们报告了三例经尸检证实的侵袭性脑曲霉病伴大口径脑血管弥漫性血管炎的回顾性病例系列。
三名患者免疫抑制：一名接受利妥昔单抗治疗，一名接受皮质类固醇治疗，一名接受肾移植。其中两名患者在死后诊断为脑曲霉病。
曲霉性脑血管炎是一种罕见的侵袭性曲霉病形式，在影像学有提示性病变的免疫功能低下个体中应考虑该诊断。它应被怀疑为无菌性中性粒细胞性脑膜炎的可能原因。
