高度受阻甾体烯烃硼氢化反应的立体化学过程。14β-和8α,14β-甾体的简便合成。
Stereochemical course of the hydroboration of highly hindered steroidal olefins. A ready synthesis of 14 beta- and 8 alpha,14 beta-steroids.
作者信息
Anastasia M, Allevi P, Fiecchi A, Oleotti A, Scala A
出版信息
Steroids. 1986 Feb-Mar;47(2-3):131-41. doi: 10.1016/0039-128x(86)90084-x.
PMID:3564083
Abstract
Hydroboration of 5 alpha-cholest-8-ene, 5 alpha,14 beta-cholest-8-ene and 5 alpha,14 beta-cholest-7-ene provides a simple route to oxygenated steroids with 14 beta- and 8 alpha,14 beta- unnatural stereochemistry.
摘要
对5α-胆甾-8-烯、5α,14β-胆甾-8-烯和5α,14β-胆甾-7-烯进行硼氢化反应，为合成具有14β-以及8α,14β-非天然立体化学结构的氧化甾体提供了一条简便途径。
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