Centre of Ophthalmology and Visual Science (incorporating Lions Eye Institute), The University of Western Australia, Perth, Australia.
Department of Optometry, The University of Western Australia, Perth, Australia.
Clin Exp Ophthalmol. 2022 Sep;50(7):736-744. doi: 10.1111/ceo.14120. Epub 2022 Jun 13.
To investigate the relationship between dietary intake of niacin (water-soluble form of vitamin B ) and retinal nerve fibre layer (RNFL) thickness in healthy eyes.
This cross-sectional study examined the association between daily niacin intake and RNFL thickness in three large population-based cohorts with varied age differences. RNFL thickness was extracted from optical coherence tomography data; energy-adjusted niacin intake was estimated from food frequency questionnaires. Linear mixed-effects models were utilised to examine the association between RNFL thickness and energy-adjusted niacin intake. Three separate analyses were conducted, with niacin treated as a continuous, a categorical (quartiles) or a dichotomous (above/below Australian recommended daily intake) variable.
In total, 4937 subjects were included in the study [Raine Study Gen2, n = 1204, median age 20; Busselton Healthy Ageing Study (BHAS), n = 1791, median age 64; TwinsUK, n = 1942, median age 64). When analysed as a continuous variable, there was no association between RNFL thickness and niacin intake in any of the three cohorts (95% CI β: Raine Study Gen 2, -0.174 to 0.074; BHAS, -0.066 to 0.078; TwinsUK -0.435 to 0.350). Similar findings were observed with quartiles of niacin intake and for niacin intakes above or below Australian recommended daily intake levels in all three cohorts.
Dietary intake of niacin from a standard diet does not appear to be associated with age-related RNFL thinning in healthy eyes. Supraphysiological doses of niacin may be required for therapeutic effect in the retina.
研究饮食中烟酸（水溶性维生素 B 形式）摄入与健康眼视网膜神经纤维层（RNFL）厚度之间的关系。
本横断面研究调查了三种具有不同年龄差异的大型人群队列中每日烟酸摄入量与 RNFL 厚度之间的关联。从光学相干断层扫描数据中提取 RNFL 厚度；从食物频率问卷中估计能量调整后的烟酸摄入量。利用线性混合效应模型检验 RNFL 厚度与能量调整后烟酸摄入量之间的关系。分别进行了三项分析，烟酸分别作为连续变量、分类（四分位数）或二分类（高于/低于澳大利亚推荐的每日摄入量）变量进行处理。
共纳入 4937 名受试者[Raine 研究 Gen2，n=1204，中位年龄 20 岁；Busselton 健康老龄化研究（BHAS），n=1791，中位年龄 64 岁；TwinsUK，n=1942，中位年龄 64 岁]。当作为连续变量进行分析时，在三个队列中，RNFL 厚度与烟酸摄入量之间均无关联（95%CIβ：Raine 研究 Gen2，-0.174 至 0.074；BHAS，-0.066 至 0.078；TwinsUK，-0.435 至 0.350）。在所有三个队列中，烟酸摄入量四分位数和高于或低于澳大利亚推荐的每日摄入量水平时，也观察到了类似的发现。
来自标准饮食的烟酸饮食摄入似乎与健康眼中与年龄相关的 RNFL 变薄无关。视网膜可能需要超生理剂量的烟酸才能产生治疗效果。
