Boyce W M, Courtney C H, Thibideau M
Vet Parasitol. 1986 Dec;22(3-4):259-66. doi: 10.1016/0304-4017(86)90113-5.
Two experiments compared the protection against oral challenge with 20 metacercariae of Fasciola hepatica conferred on rats by intraperitoneal injection of serum from three breeds of sheep infected with F. hepatica (Barbados Blackbelly, St. Croix, Florida Native). Experiment 1 used serum from sheep 5-6 months of age following two infections of 250 metacercariae each, while Experiment 2 utilized serum collected from the same sheep at 10-11 months of age following either a primary (first exposure) or challenge (after two previous exposures of 250 metacercariae each) infection with 500 metacercariae. Similar numbers of flukes were recovered from rats given either immune or nonimmune (control) serum from each breed of sheep in Experiment 1. In Experiment 2, rats given serum from infected St. Croix sheep had significantly fewer flukes than rats given either control or immune serum from Barbados Blackbelly or Florida Native sheep. There was no significant correlation of fluke counts between individual serum donors (sheep) and serum recipients (rats).
两项实验比较了腹腔注射感染肝片吸虫（巴巴多斯黑腹羊、圣克罗伊羊、佛罗里达本地羊）的三个品种绵羊的血清后，对大鼠抵御20个肝片吸虫囊蚴经口攻击的保护作用。实验1使用的是5至6月龄绵羊在两次各感染250个囊蚴后的血清，而实验2使用的是相同绵羊在10至11月龄时，经500个囊蚴初次感染（首次接触）或攻击感染（之前两次各接触250个囊蚴之后）后采集的血清。在实验1中，给大鼠注射各品种绵羊的免疫血清或非免疫（对照）血清后，回收的吸虫数量相似。在实验2中，给大鼠注射感染圣克罗伊羊的血清后，其体内的吸虫数量显著少于注射巴巴多斯黑腹羊或佛罗里达本地羊的对照血清或免疫血清的大鼠。在个体血清供体（绵羊）和血清受体（大鼠）之间，吸虫计数没有显著相关性。
