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[肾上腺病理生理学的当前问题及其临床重要性]

[Current problems in the pathophysiology of the adrenal glands and its clinical importance].

作者信息

Kaiser W, Schmidt G A

出版信息

Z Gesamte Inn Med. 1978 Jun 15;33(12):377-83.

PMID:356442
Abstract

In recent years new knowledge on the pathophysiolgy of the parathyroid gland has led to a series of not unimportant consequences for the endocrinological clinic. To this belongs the glandular translocation which under certain circumstances is regarded as favourable and the principal practicability so which is without any question. In certain, above all urologically conditioned clinical pictures with consecutive stimulation of the parathyroid secretion an inhibition effect on the parathyroid glands which can be evoked by drugs is discussed. Here the problem is a possibly significant preventive measure. The question of the maintained or disturbed euparathyroidism must be interesting in such cases, in which alone from the result of the conventional calcium-metabolic diagnostics an obligatory evidence remains questionable. Difficulties are above all in such cases, where the transitions of a functional adaption mechanism to an autonomized process with own laws may be present or it must be feared that the overloaded glandular function comes to an end. On the basis of own findings the authors adopt a definite attitude to these problems.

摘要

近年来,甲状旁腺病理生理学的新知识给内分泌临床带来了一系列相当重要的影响。这其中包括在某些情况下被视为有利的腺体移位以及毫无争议的主要实用性。在某些情况下,尤其是在泌尿系统疾病导致的临床症状并伴有甲状旁腺分泌连续刺激的情况下,会讨论药物对甲状旁腺的抑制作用。这里的问题是一种可能具有重要意义的预防措施。在仅从传统钙代谢诊断结果难以得出确凿证据的此类病例中,维持或扰乱甲状旁腺功能正常的问题必然引人关注。尤其在可能存在从功能性适应机制向具有自身规律的自主过程转变,或者担心超负荷的腺功能终止的情况下,困难尤为突出。基于自身的研究结果,作者对这些问题采取了明确的态度。

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