McGill University, Department of Psychology, 2001 McGill College Avenue, Montreal, QC H3A 1G1, Canada.
McGill University, Department of Psychology, 2001 McGill College Avenue, Montreal, QC H3A 1G1, Canada.
Biol Psychol. 2022 Jul;172:108363. doi: 10.1016/j.biopsycho.2022.108363. Epub 2022 May 26.
Anhedonia is present in diverse psychiatric disorders and has been linked to reduced neural responses to reward. However, most studies of anhedonia have used monetary reward, making it unclear whether previously-observed deficits represent broad domain-general impairments, or whether associations with anhedonia might vary across incentive types. The present study (N = 120) investigated associations between multiple measures of self-reported anhedonia and reward responsiveness and the reward positivity (RewP), a neural index of reward processing, following monetary, social, and food reward. Greater social anhedonia was associated with a smaller RewP following positive social feedback, whereas reduced consummatory pleasure was associated with a smaller RewP following food reward. Associations among both self-report and neural measures of reward sensitivity were generally modest. Our findings suggest that neither anhedonia nor neural reward sensitivity are unidimensional constructs, and that category-specific reward deficits might better capture specific problems in hedonic functioning.
快感缺失存在于多种精神障碍中，并与对奖励的神经反应减弱有关。然而，快感缺失的大多数研究都使用了金钱奖励，这使得之前观察到的缺陷是否代表广泛的领域一般性损伤，或者与快感缺失的关联是否可能因奖励类型而异尚不清楚。本研究（N=120）调查了多种自我报告的快感缺失和奖励反应的测量值与奖励正波（RewP）之间的关联，RewP 是一种奖励处理的神经指标，用于奖励金钱、社会和食物。在积极的社会反馈后，更大的社会快感缺失与更小的 RewP 相关，而在食物奖励后，消费快感的减少与更小的 RewP 相关。自我报告和神经奖励敏感性测量值之间的关联通常是适度的。我们的研究结果表明，快感缺失和神经奖励敏感性都不是单一维度的结构，并且特定类别的奖励缺陷可能更好地捕捉到愉悦功能的特定问题。
