Szenczy A K, Adams E M, Hawes M T, Anatala J, Gair K, Klein D N, Hajcak G, Nelson B D
Stony Brook University, Stony Brook, NY, USA.
Santa Clara University, Santa Clara, CA, USA.
Dev Psychopathol. 2025 May;37(2):825-835. doi: 10.1017/S0954579424000701. Epub 2024 May 17.
The reward positivity (RewP) is an event-related potential that indexes reinforcement learning and reward system activation. The RewP has been shown to increase across adolescence; however, most studies have examined the RewP across two assessments, and no studies have examined within-person changes across adolescence into young adulthood. Moreover, the RewP has been identified as a neurobiological risk factor for adolescent-onset depression, but it is unclear whether childhood psychosocial risk factors might predict RewP development across adolescence. In a sample of 317 8- to 14-year-old girls ( = 12.4, = 1.8), the present study examined self-report measures of depression symptoms and stressful life events at baseline and the ΔRewP during the doors guessing task across three timepoints. Growth modeling indicated that, across all participants, the ΔRewP did not demonstrate linear change across adolescence. However, baseline anhedonia symptoms predicted within-person changes in the ΔRewP, such that individuals with low anhedonia symptoms demonstrated a linear increase in the ΔRewP, but individuals with high anhedonia symptoms had no change in the ΔRewP across adolescence. Similar patterns were observed for stressful life events. The present study suggests that childhood risk factors impact the development of reward-related brain activity, which might subsequently increase risk for psychopathology.
奖赏正性（RewP）是一种与事件相关的电位，可作为强化学习和奖赏系统激活的指标。研究表明，RewP在整个青春期都会增加；然而，大多数研究是通过两次评估来考察RewP的，尚无研究考察从青春期到青年期个体内部的变化情况。此外，RewP已被确定为青少年期抑郁症的一种神经生物学危险因素，但尚不清楚儿童期心理社会危险因素是否能预测整个青春期RewP的发展。在一个由317名8至14岁女孩组成的样本中（平均年龄 = 12.4岁，标准差 = 1.8岁），本研究在三个时间点考察了基线时抑郁症状和应激性生活事件的自我报告测量指标，以及猜门任务期间的RewP变化量（ΔRewP）。生长模型表明，在所有参与者中，ΔRewP在青春期并未呈现线性变化。然而，基线时的快感缺失症状可预测个体内部ΔRewP的变化，即快感缺失症状较轻的个体，其ΔRewP呈线性增加，而快感缺失症状较重的个体，其ΔRewP在整个青春期没有变化。应激性生活事件也观察到了类似的模式。本研究表明，儿童期危险因素会影响与奖赏相关的大脑活动的发展，这可能随后增加精神病理学风险。
