Institut Pasteur, Université́ Paris Cité, Inserm UMR1222, Unit of Antibodies in Therapy and Pathology, F-75015 Paris, France; Inflammation, Microbiome and Immunosurveillance, Université Paris-Saclay, INSERM, Châtenay-Malabry, France.
Institut Pasteur, Université́ Paris Cité, Inserm UMR1222, Unit of Antibodies in Therapy and Pathology, F-75015 Paris, France; Inflammation, Microbiome and Immunosurveillance, Université Paris-Saclay, INSERM, Châtenay-Malabry, France; APHP, Bichat Hospital, Immunology Department, F-75018 Paris, France.
Int J Biochem Cell Biol. 2022 Jun;147:106231. doi: 10.1016/j.biocel.2022.106231. Epub 2022 May 26.
Autoimmune cytopenias are a consequence of autoantibodies that target blood cell lineages and mark them for their accelerated destruction, mostly through phagocytosis by monocytes and macrophages and complement activation. Neutrophils, although equipped with Fc and complement receptors and effector mechanisms that are critical in other autoimmune conditions, remained long overlooked. Recent reports, however, propose a new and possibly critical role of neutrophils. In this review, we gathered available evidence on the contribution of neutrophils to the development, onset, and consequences of autoantibody-dependent cytopenias.
自身免疫性血细胞减少症是自身抗体靶向血细胞谱系的结果，并标记它们加速破坏，主要通过单核细胞和巨噬细胞吞噬和补体激活。中性粒细胞虽然具有在其他自身免疫性疾病中至关重要的 Fc 和补体受体以及效应机制，但长期以来一直被忽视。然而，最近的报告提出了中性粒细胞的新的、可能关键的作用。在这篇综述中，我们收集了关于中性粒细胞对依赖自身抗体的血细胞减少症的发展、发作和后果的贡献的现有证据。
