Tumor Biomechanics, Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche S1109, Strasbourg, France; Université de Strasbourg, Strasbourg, France; Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France; Equipe Labellisée Ligue Contre le Cancer, Strasbourg, France.
Tumor Biomechanics, Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche S1109, Strasbourg, France; Université de Strasbourg, Strasbourg, France; Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France; Equipe Labellisée Ligue Contre le Cancer, Strasbourg, France.
Trends Cancer. 2022 Oct;8(10):799-805. doi: 10.1016/j.trecan.2022.05.002. Epub 2022 May 26.
The intravascular behavior of tumor-derived extracellular vesicles (EVs) and circulating tumor cells (CTCs) lies at the heart of the metastatic cascade. Their capacity to disseminate and stop at specific vascular regions precedes and determines the formation of metastatic foci. We discuss in detail the central role of cellular adhesion molecules (CAMs) that are present on EV/CTC surface, as well as their endothelial ligands, in dictating their arrest site and their capacity to exit the vasculature. We focus on the differences and similarities between CAMs on CTCs and EVs, and speculate about their role in the organotropism of different cancer types. Better understanding of the binding mechanisms might pinpoint potential targets for novel therapies.
肿瘤来源的细胞外囊泡（EVs）和循环肿瘤细胞（CTCs）的血管内行为是转移级联的核心。它们在特定血管区域传播和停留的能力先于并决定了转移灶的形成。我们详细讨论了存在于 EV/CTC 表面的细胞黏附分子（CAMs）及其内皮配体在决定其停留部位和从血管逸出能力方面的核心作用。我们专注于 CTCs 和 EVs 上 CAMs 的差异和相似之处，并推测它们在不同癌症类型的器官趋向性中的作用。更好地了解结合机制可能会确定新疗法的潜在靶点。
