Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Curr Opin Obstet Gynecol. 2022 Jun 1;34(3):107-113. doi: 10.1097/GCO.0000000000000783.
To succinctly review the basic mechanisms of implantation and luteal phase endometrial differentiation, the etiologies of impaired endometrial function and receptivity, and the current methods that exist to evaluate and treat impaired endometrial receptivity.
Human embryo implantation requires bidirectional communication between blastocyst and a receptive endometrium. Etiologies of impaired endometrial receptivity are varied. Some of these include delayed endometrial maturation, structural abnormalities, inflammation, and progesterone resistance. Current methods to evaluate endometrial receptivity include ultrasonography, hysteroscopy, and endometrial biopsy. Treatments are limited, but include operative hysteroscopy, treatment of endometriosis, and personalized timing of embryo transfer.
Although some mechanisms of impaired endometrial receptivity are well understood, treatment options remain limited. Future efforts should be directed towards developing interventions targeted towards the known mediators of impaired endometrial receptivity.
简要回顾着床的基本机制和黄体期子宫内膜的分化，子宫内膜功能和容受性受损的病因，以及目前评估和治疗子宫内膜容受性受损的方法。
人类胚胎着床需要胚泡和接受性子宫内膜之间的双向通讯。子宫内膜容受性受损的病因多种多样。其中一些包括子宫内膜成熟延迟、结构异常、炎症和孕激素抵抗。目前评估子宫内膜容受性的方法包括超声检查、宫腔镜检查和子宫内膜活检。治疗方法有限，但包括宫腔镜手术、子宫内膜异位症的治疗和胚胎移植的个体化时机。
尽管子宫内膜容受性受损的一些机制已经得到很好的理解，但治疗选择仍然有限。未来的研究应致力于开发针对已知子宫内膜容受性受损介质的干预措施。
