辉瑞-BioNTech COVID-19 疫苗诱导的偏侧舞蹈-投掷症的临床和放射学随访。
Clinical and Radiological Follow-Up of a Pfizer-BioNTech COVID-19 Vaccine-Induced Hemichorea-Hemiballismus.
机构信息
Neurology Unit, AP-HP, Avicenne University Hospital, Sorbonne Paris Nord, Bobigny, France.
Department of Nuclear Medicine Unit, AP-HP, Avicenne University Hospital, Sorbonne Paris Nord, Bobigny, France.
出版信息
Tremor Other Hyperkinet Mov (N Y). 2022 May 18;12:16. doi: 10.5334/tohm.688. eCollection 2022.
BACKGROUND
Hemichorea-hemiballismus is a rare hyperkinetic movement disorder.
CASE REPORT
A 90-year-old male developed left hemichorea-hemiballismus after his second dose of the Pfizer-BioNTech COVID-19 vaccine. A wide range of investigations including magnetic resonance imaging did not reveal an alternative cause. [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) showed increases in right putamen fixation compared to the left side. The patient showed significant improvement after five days of intravenous corticosteroids, with a normal FDG-PET.
DISCUSSION
This hemichorea-hemiballismus case shows dynamic restoration of putamen metabolism mirroring clinical evolution after administration of corticosteroids, suggesting an autoimmune COVID-19 vaccine-induced reaction.
背景
偏侧舞动-偏侧投掷症是一种罕见的运动障碍。
病例报告
一名 90 岁男性在接种第二剂辉瑞-生物科技公司的 COVID-19 疫苗后出现左侧偏侧舞动-偏侧投掷症。包括磁共振成像在内的广泛检查并未发现其他病因。[18F]-氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）显示右侧壳核固定较左侧增加。患者在接受五天静脉注射皮质类固醇后症状显著改善，FDG-PET 正常。
讨论
该例偏侧舞动-偏侧投掷症病例显示壳核代谢的动态恢复，与皮质类固醇治疗后的临床演变相吻合，提示可能是由 COVID-19 疫苗诱导的自身免疫反应引起。
Zotero 插件