Kakuta Kiyohide, Asano Kenichiro, Shimamura Norihito, Kurose Akira, Ohkuma Hiroki
Department of Neurosurgery, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.
Department of Anatomic Pathology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.
NMC Case Rep J. 2022 Apr 28;9:89-94. doi: 10.2176/jns-nmc.2021-0350. eCollection 2022.
A dysembryoplastic neuroepithelial tumor (DNT) is a benign neoplasm that usually occurs in the supratentorial cerebral cortex. Here, we report a rare case of an infratentorial DNT in a 42-year-old woman who presented with dizziness and a gait disturbance. Magnetic resonance imaging of the lesion demonstrated hyperintensity on T2-weighted images and hypointensity on T1-weighted images of the left cerebellar hemisphere with a multifocal lesion. Macroscopically, the lesion appeared soft, avascular, and slightly torose at the cortical surface. Histologically, dysplastic disorganization of the cortex and floating neurons were observed. The pathological and immunochemical features of this case agree with the diagnosis of a DNT. The lesion partially included cortical heterotopia, which is a novel observation in an infratentorial DNT. On the basis of the previous reports, we discussed the surgical resection of the infratentorial DNT.
胚胎发育不良性神经上皮肿瘤(DNT)是一种通常发生于幕上大脑皮质的良性肿瘤。在此,我们报告一例罕见的幕下DNT病例,患者为一名42岁女性,表现为头晕和步态障碍。病变的磁共振成像显示左侧小脑半球在T2加权图像上呈高信号,在T1加权图像上呈低信号,为多灶性病变。大体上,病变在皮质表面显得柔软、无血管且略呈结节状。组织学上,观察到皮质发育异常紊乱和漂浮神经元。该病例的病理和免疫组化特征符合DNT的诊断。病变部分包含皮质异位,这在幕下DNT中是一项新发现。基于既往报道,我们讨论了幕下DNT的手术切除。