Wang Zhou, Ma Jiwei
Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Front Neurol. 2024 Jan 5;14:1309209. doi: 10.3389/fneur.2023.1309209. eCollection 2023.
Multinodular and vacuolar neuronal tumor (MVNT) is a rare and benign neuroepithelial tumor. Most reports describe tumors located in the cerebral hemisphere. A literature review found that 15 cases were located in the posterior cranial fossa, but all lacked pathological evidence. In this case, a patient sought medical attention due to insomnia and irritability. Neuroepithelial tumors were found in the imaging, and the patient underwent radiation therapy. Three years later, malignant tumors were found upon imaging examination. After surgical resection and pathological testing, MVNT occurring in the cerebellum was diagnosed. MVNT is rare in the cerebellum, and direct imaging diagnosis becomes difficult after treatment. Therefore, our report of this case helps to further accurate understanding of the imaging, pathological, and molecular genetic changes occurring before and after MVNT treatment, and will improve the accuracy of pre-treatment diagnosis and reduce the likelihood of overtreatment.
多结节空泡状神经元肿瘤(MVNT)是一种罕见的良性神经上皮肿瘤。大多数报道描述的肿瘤位于大脑半球。一项文献综述发现,有15例位于后颅窝,但均缺乏病理证据。在本病例中,一名患者因失眠和易怒前来就医。影像学检查发现神经上皮肿瘤,该患者接受了放射治疗。三年后,影像学检查发现恶性肿瘤。经手术切除和病理检查,诊断为发生在小脑的MVNT。MVNT在小脑中罕见,治疗后直接进行影像学诊断变得困难。因此,我们对该病例的报告有助于进一步准确了解MVNT治疗前后发生的影像学、病理及分子遗传学变化,并将提高治疗前诊断的准确性,降低过度治疗的可能性。