van Lith Theresa J, Sluis Wouter M, Wijers Naomi T, Meijer Frederick Ja, Kamphuis-van Ulzen Karin, de Bresser Jeroen, Dankbaar Jan Willem, van den Heuvel Frederik Ma, Antoni M Louisa, Mulders-Manders Catharina M, de Mast Quirijn, van de Veerdonk Frank L, Klok Frederikus A, Tuladhar Anil M, Cannegieter Suzanne C, Wermer Marieke Jh, van der Worp H Bart, Huisman Menno V, de Leeuw Frank-Erik
Department of Neurology, Donders Center for Medical Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.
Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Eur Stroke J. 2022 Jun;7(2):180-187. doi: 10.1177/23969873221092538. Epub 2022 Apr 6.
COVID-19 is often complicated by thrombo-embolic events including ischemic stroke. The underlying mechanisms of COVID-19-associated ischemic stroke, the incidence and risk factors of silent cerebral ischemia, and the long-term functional outcome in these patients are currently unknown.
CORONavirus and Ischemic Stroke (CORONIS) is a multicentre prospective cohort study investigating the prevalence, risk factors and long-term incidence of (silent) cerebral ischemia, and the long-term functional outcome among patients with COVID-19. We aim to include 200 adult patients hospitalized with COVID-19 without symptomatic ischemic stroke to investigate the prevalence of silent cerebral ischemia compared with 60 (matched) controls with MRI. In addition, we will identify potential risk factors and/or causes of cerebral ischemia in COVID-19 patients with ( = 70) or without symptomatic stroke ( = 200) by means of blood sampling, cardiac workup and brain MRI. We will measure functional outcome and cognitive function after 3 and 12 months with standardized questionnaires in all patients with COVID-19. Finally, the long-term incidence of (new) silent cerebral ischemia in patients with COVID-19 will be assessed with follow up MRI ( = 120).
The CORONIS study is designed to add further insight into the prevalence, long-term incidence and risk factors of cerebral ischemia, and the long-term functional outcome in hospitalized adult patients with COVID-19.
新型冠状病毒肺炎（COVID-19）常并发血栓栓塞事件，包括缺血性中风。目前，COVID-19相关缺血性中风的潜在机制、无症状脑缺血的发生率和危险因素，以及这些患者的长期功能结局尚不清楚。
冠状病毒与缺血性中风（CORONIS）是一项多中心前瞻性队列研究，旨在调查（无症状）脑缺血的患病率、危险因素和长期发生率，以及COVID-19患者的长期功能结局。我们的目标是纳入200例因COVID-19住院且无症状性缺血性中风的成年患者，与60例（匹配的）接受MRI检查的对照者比较，以研究无症状脑缺血的患病率。此外，我们将通过血液采样、心脏检查和脑部MRI，确定有症状性中风（n = 70）或无症状性中风（n = 200）的COVID-19患者脑缺血的潜在危险因素和/或病因。我们将使用标准化问卷对所有COVID-19患者在3个月和12个月后测量功能结局和认知功能。最后，将通过随访MRI（n = 120）评估COVID-19患者（新的）无症状脑缺血的长期发生率。
CORONIS研究旨在进一步深入了解脑缺血的患病率、长期发生率和危险因素，以及COVID-19住院成年患者的长期功能结局。
