Taguchi Keita, Iwaoka Kazuhiro, Yamaguchi Takashi, Nozaki Ryota, Sato Yuriko, Terauchi Takahiro, Suzuki Yoshio, Takahashi Kai, Takahashi Kenta, Akasaka Hiroshi, Ishizuka Naoki, Maeda Tetsuya
Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Shiwa, Iwate 0283694, Japan.
Clin Park Relat Disord. 2022 May 21;7:100147. doi: 10.1016/j.prdoa.2022.100147. eCollection 2022.
Parkinson's disease (PD) is more prevalent in the aging population, and epidemiological evidence must be constantly updated to provide an accurate understanding of PD prevalence. Various nonmotor symptoms of PD precede the onset of motor symptoms and prodromal PD. The detection of such symptoms is crucial yet remains challenging. In this study, we aimed to clarify the current prevalence of PD and prodromal PD.
We enrolled 714 community-dwelling older adults (330 men and 384 women) aged ≥ 65 years (mean age 76.3 years). We used a self-administered questionnaire based on the International Parkinson and Movement Disorder Society prodromal PD criteria to obtain information on prodromes and calculate PD probability. Patients with a probability of ≥ 0.3 were considered as having prodromal PD. We analyzed the crude prevalence rates of PD and prodromal PD.
The crude prevalence rate of PD in our sample was 279.7 per 100,000 persons. The crude prevalence rate of prodromal PD and PD probability were 5034.5 per 100,000 persons and 0.057 ± 0.121, respectively. Never smoker (61.4%), physical inactivity (47.0%), regular pesticide exposure (30.7%), and urinary dysfunction (26.5%) were frequent positive prodromes. Subjects with higher PD probability possessed more variable prodromal markers than those with lower probability.
We examined current prevalence rates of PD and prodromal PD in community-dwelling older adults aged ≥ 65 years in Japan. Our questionnaire-based approach to examine prodromal PD provided valuable evidence for the prevalence of prodromal PD in the aging population.
帕金森病（PD）在老年人群中更为普遍，必须不断更新流行病学证据，以便准确了解PD的患病率。PD的各种非运动症状先于运动症状和前驱期PD出现。检测这些症状至关重要，但仍具有挑战性。在本研究中，我们旨在阐明当前PD和前驱期PD的患病率。
我们纳入了714名年龄≥65岁（平均年龄76.3岁）的社区居住老年人（330名男性和384名女性）。我们使用基于国际帕金森和运动障碍协会前驱期PD标准的自填问卷来获取前驱症状信息并计算患PD的概率。概率≥0.3的患者被视为患有前驱期PD。我们分析了PD和前驱期PD的粗患病率。
我们样本中PD的粗患病率为每10万人279.7例。前驱期PD的粗患病率和患PD的概率分别为每10万人5034.5例和0.057±0.121。从不吸烟者（61.4%）、缺乏身体活动（47.0%）、经常接触农药（30.7%）和排尿功能障碍（26.5%）是常见的阳性前驱症状。PD概率较高的受试者比概率较低的受试者拥有更多可变的前驱标志物。
我们调查了日本≥65岁社区居住老年人中PD和前驱期PD的当前患病率。我们基于问卷的前驱期PD检测方法为老年人群前驱期PD的患病率提供了有价值的证据。
