Maeda Tetsuya, Shimo Yasushi, Chiu Shih-Wei, Yamaguchi Takuhiro, Kashihara Kenichi, Tsuboi Yoshio, Nomoto Masahiro, Hattori Nobutaka, Watanabe Hirohisa, Saiki Hidemoto
Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate 020-8505, Japan; Department of Neurology and Movement Disorder Research, Research Institute for Brain and Blood Vessels-Akita, 6-10 Senshukubotamachi, Akita 010-0874, Japan.
Department of Neurology, Juntendo University School of Medicine 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-8431, Japan.
Parkinsonism Relat Disord. 2017 May;38:54-60. doi: 10.1016/j.parkreldis.2017.02.024. Epub 2017 Feb 21.
We aimed to investigate the prevalence and severity of nonmotor symptoms (NMSs) and to identify factors affecting NMSs and the health-related quality of life of Japanese patients with Parkinson's disease (PD).
A total of 1021 patients with PD who had one or more NMS and showed wearing-off under anti-parkinsonian treatment were enrolled from 35 medical centers in Japan for this observational study. The primary measurements were the Movement Disorder Society unified Parkinson's disease rating scale (MDS-UPDRS) part I and the Parkinson's Disease Questionnaire (PDQ-8). The relationships of MDS-UPDRS and PDQ-8 with the patient's clinical background and undertaken medical interventions were determined. Here, we report baseline data of our 52-week ongoing study.
The mean MDS-UPDRS part I and PDQ-8 scores were 10.9 and 7.3, respectively. The most common NMSs were constipation problems (85.4%), sleep problems (73.7%), pain and other sensations (72.7%) and daytime sleepiness (72.0%). Fatigue was an NMS that affected 79.6% of females but only 72.6% of males, whereas features of dopamine dysregulation syndrome affected only 5.6% of females and 10.8% of males. Positive correlations were found between the MDS-UPDRS part I and the PDQ-8 (p < 0.0001, r = 0.56) and between the number of NMSs and the PDQ-8 score (p < 0.0001, r = 0.47).
This study revealed distinctive patterns of NMSs in Japanese patients with PD and suggested that the prevalence and severity of NMSs vary between sexes, and that the NMSs are important factors affecting the long-term quality of life of PD patients.
我们旨在调查非运动症状（NMSs）的患病率和严重程度，并确定影响日本帕金森病（PD）患者非运动症状及健康相关生活质量的因素。
本观察性研究从日本35个医疗中心招募了1021例患有一种或多种非运动症状且在抗帕金森病治疗下出现疗效减退的帕金森病患者。主要测量指标为运动障碍协会统一帕金森病评定量表（MDS-UPDRS）第一部分和帕金森病问卷（PDQ-8）。确定了MDS-UPDRS和PDQ-8与患者临床背景及所接受医疗干预之间的关系。在此，我们报告我们正在进行的为期52周研究的基线数据。
MDS-UPDRS第一部分和PDQ-8的平均得分分别为10.9和7.3。最常见的非运动症状是便秘问题（85.4%）、睡眠问题（73.7%）、疼痛及其他感觉（72.7%）和日间嗜睡（72.0%）。疲劳是一种非运动症状，影响了79.6%的女性，但仅影响了72.6%的男性，而多巴胺调节障碍综合征的特征仅影响了5.6%的女性和10.8%的男性。MDS-UPDRS第一部分与PDQ-8之间（p < 0.0001，r = 0.56）以及非运动症状数量与PDQ-8得分之间（p < 0.0001，r = 0.47）均存在正相关。
本研究揭示了日本帕金森病患者非运动症状的独特模式，并表明非运动症状的患病率和严重程度在性别之间存在差异，且非运动症状是影响帕金森病患者长期生活质量的重要因素。
