Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi; Department of Ophthalmology, CGHS, Prayagraj, Uttar Pradesh, India.
Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Indian J Ophthalmol. 2022 Jun;70(6):1963-1970. doi: 10.4103/ijo.IJO_2885_21.
To compare the efficacy of physiological, non-detergent eyelid wipes with conventional lid hygiene in patients with meibomian gland dysfunction (MGD).
Fifty participants with MGD were recruited and randomized into two groups. Participants in group I used Evolve Pure™ Eyewipes twice a day to clean the eyelid debris along with standard therapy (antibiotic and lubricants) and participants in group II followed lid hygiene with warm compresses along with standard therapy. Symptoms, ocular surface assessment (lipid layer thickness, tear meniscus height, non-invasive tear film breakup time, and meibography), slit-lamp biomicroscopy (eyelash contamination, meibomian gland blockage, meibomian gland secretion, and meibomian gland telangiectasia) and tear film osmolarity were noted at baseline and 90 days after therapy.
Significant improvement in symptoms and signs of MGD was observed in both groups after treatment (P < 0.001); however, the clinical improvement was better with the use of eyelid wipes. Lipid layer thickness increased significantly in group I (P = 0.0006) and group II (P = 0.0002), which was maintained even after adjusting for sociodemographic variables such as age, sex, and severity score of symptoms and signs.
Lipid layer thickness of the tear film is a sensitive marker in monitoring response to treatment in patients with MGD. The use of physiological detergent-free eyelid wipes is non-inferior to lid hygiene and warm compresses, which remains the mainstay for treatment of MGD; the clinical improvement with eyelid wipes was noted to be better.
比较生理性、无清洁剂的眼睑擦拭与传统眼睑卫生在睑板腺功能障碍（MGD）患者中的疗效。
招募了 50 名 MGD 患者，并将其随机分为两组。组 I 患者每天使用 Evolve Pure™ 湿巾两次清洁眼睑碎屑，并辅以标准治疗（抗生素和润滑剂）；组 II 患者采用温热敷法进行眼睑卫生，并辅以标准治疗。在基线和治疗 90 天后，记录症状、眼表评估（脂质层厚度、泪膜月牙高度、非侵入性泪膜破裂时间和睑板腺照相）、裂隙灯生物显微镜检查（睫毛污染、睑板腺阻塞、睑板腺分泌物和睑板腺毛细血管扩张）和泪膜渗透压。
两组治疗后 MGD 的症状和体征均显著改善（P<0.001）；然而，使用眼睑擦拭的临床改善更好。组 I（P=0.0006）和组 II（P=0.0002）的脂质层厚度均显著增加，即使在调整年龄、性别和症状与体征严重程度评分等社会人口学变量后，这种增加仍得以维持。
泪膜脂质层厚度是监测 MGD 患者治疗反应的敏感标志物。使用生理性、无清洁剂的眼睑擦拭与眼睑卫生和温热敷法一样有效，仍是治疗 MGD 的主要方法；与眼睑卫生和温热敷法相比，眼睑擦拭的临床改善更为显著。
