Department of Cardiology, Third Xiang-Ya Hospital, Central South University, 138 Tongzipo Road, Changsha, 410013, Hunan, China.
Department of Cardiology, Third Hospital of Changsha, 176 W. Laodong Road, Changsha, 410015, Hunan, China.
J Cardiovasc Transl Res. 2022 Dec;15(6):1283-1296. doi: 10.1007/s12265-022-10275-4. Epub 2022 Jun 1.
Atherosclerosis is a chronic inflammatory disease that poses a huge economic burden due to its extremely poor prognosis. Therefore, it is necessary to explore potential mechanisms to improve the prevention and treatment of atherosclerosis. A disintegrin and metalloprotease 17 (ADAM17) is a cell membrane-bound protein that performs a range of functions through membrane protein shedding and intracellular signaling. ADAM17-mediated inflammation has been identified to be an important contributor to atherosclerosis; however, the specific relationship between its multiple regulatory roles and the pathogenesis of atherosclerosis remains unclear. Here, we reviewed the activation, function, and regulation of ADAM17, described in detail the role of ADAM17-mediated inflammatory damage in atherosclerosis, and discussed several controversial points. We hope that these insights into ADAM17 biology will lead to rational management of atherosclerosis. ADAM17 promotes vascular inflammation in endothelial cells, smooth muscle cells, and macrophages, and regulates the occurrence and development of atherosclerosis.
动脉粥样硬化是一种慢性炎症性疾病，由于其预后极差，因此造成了巨大的经济负担。因此，有必要探索潜在的机制来改善动脉粥样硬化的预防和治疗。解整合素金属蛋白酶 17（ADAM17）是一种细胞膜结合蛋白，通过膜蛋白脱落和细胞内信号转导发挥多种功能。ADAM17 介导的炎症被认为是动脉粥样硬化的一个重要贡献者；然而，其多种调节作用与动脉粥样硬化发病机制之间的具体关系尚不清楚。在这里，我们回顾了 ADAM17 的激活、功能和调节，详细描述了 ADAM17 介导的炎症损伤在动脉粥样硬化中的作用，并讨论了几个有争议的问题。我们希望这些对 ADAM17 生物学的见解将有助于合理地管理动脉粥样硬化。ADAM17 促进内皮细胞、平滑肌细胞和巨噬细胞中的血管炎症，并调节动脉粥样硬化的发生和发展。
