Key Laboratory of Marine Drugs Chinese Ministry of Education, Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Department of Chemistry, State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, China.
Chem Commun (Camb). 2022 Jun 21;58(50):7066-7069. doi: 10.1039/d2cc01528e.
Herein, we discover the new reactivity of the 1,3,5-triazine moiety reacting with a phenol group and report the development of biocompatible and catalyst-free triazine-pyridine chemistry (TPC) for tyrosine labelling under physiological conditions and profiling in the whole proteome. TPC exhibited high tyrosine chemoselectivity in biological systems after cysteine blocking, displayed potential in tyrosine-guided protein labelling, and had bio-compatibility in live cells.
在这里，我们发现 1,3,5-三嗪部分与酚基团发生新的反应，并报告了生物相容性和无催化剂三嗪-吡啶化学（TPC）的发展，用于在生理条件下对酪氨酸进行标记和对整个蛋白质组进行分析。在半胱氨酸阻断后，TPC 在生物体系中表现出高酪氨酸化学选择性，在酪氨酸引导的蛋白质标记中显示出潜力，并且在活细胞中具有生物相容性。
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