Department of Microbiology, College of Natural Sciences, Chungbuk National University, Cheongju, Republic of Korea.
Bionanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea.
Transbound Emerg Dis. 2022 Sep;69(5):e3297-e3304. doi: 10.1111/tbed.14601. Epub 2022 Jun 6.
The ongoing coronavirus disease 2019 pandemic and its overlap with the influenza season lead to concerns over severe disease caused by the influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) co-infections. Using a Syrian hamster co-infection model with SARS-CoV-2 and the pandemic influenza virus A/California/04/2009 (H1N1), we found (a) more severe disease in co-infected animals, compared to those infected with influenza virus alone but not SARS-CoV-2 infection alone; (b) altered haematological changes in only co-infected animals and (c) altered influenza virus tropism in the respiratory tracts of co-infected animals. Overall, our study revealed that co-infection with SARS-CoV-2 and influenza virus is associated with altered disease severity and tissue tropism, as well as haematological changes, compared to infection with either virus alone.
持续的 2019 年冠状病毒病（COVID-19）大流行及其与流感季节的重叠，引起了人们对流感病毒和严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）合并感染引起的严重疾病的关注。我们使用 SARS-CoV-2 和大流行流感病毒 A/加利福尼亚/04/2009（H1N1）的叙利亚仓鼠合并感染模型发现：（a）与单独感染流感病毒但不单独感染 SARS-CoV-2 的动物相比，合并感染动物的疾病更严重；（b）仅在合并感染动物中出现改变的血液学变化；（c）合并感染动物呼吸道中流感病毒的嗜性改变。总的来说，与单独感染任何一种病毒相比，我们的研究表明，SARS-CoV-2 和流感病毒的合并感染与疾病严重程度和组织嗜性以及血液学变化的改变有关。
