Thomsen K, Riis B, Krabbe S, Christiansen C
Acta Paediatr Scand. 1986 Sep;75(5):793-6. doi: 10.1111/j.1651-2227.1986.tb10292.x.
In a longitudinal study of male puberty 20 boys were examined every three months for at least two years. Haemoglobin concentration was determined and related to changes in serum testosterone concentrations. The data show a steep increase in serum testosterone during puberty (p less than 0.001) followed with a five months delay, by a significant increase in haemoglobin concentration (p less than 0.001). It is concluded that the steep increase in serum testosterone during puberty produces an acute stimulation of erythropoietin leading to an increase in erythrocyte production and thereby to a detectable increase in haemoglobin concentration a few months thereafter. The present study supports the idea that the selection of the relevant reference range for haemoglobin in boys should depend on the state of physical developments as expressed by serum testosterone.
在一项关于男性青春期的纵向研究中，每三个月对20名男孩进行检查，至少持续两年。测定血红蛋白浓度，并将其与血清睾酮浓度的变化相关联。数据显示，青春期期间血清睾酮急剧增加（p<0.001），随后延迟五个月，血红蛋白浓度显著增加（p<0.001）。得出的结论是，青春期期间血清睾酮的急剧增加会对促红细胞生成素产生急性刺激，导致红细胞生成增加，从而在几个月后血红蛋白浓度出现可检测到的增加。本研究支持这样一种观点，即男孩血红蛋白相关参考范围的选择应取决于血清睾酮所表达的身体发育状态。
