WNK1 激酶信号在转移和血管生成中的作用。
WNK1 kinase signaling in metastasis and angiogenesis.
机构信息
Institute of Molecular and Genomic Medicine, National Health Research Institute, Taiwan; Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan.
Institute of Molecular and Genomic Medicine, National Health Research Institute, Taiwan.
出版信息
Cell Signal. 2022 Aug;96:110371. doi: 10.1016/j.cellsig.2022.110371. Epub 2022 May 29.
With-no-lysine kinases (WNKs) are a novel family of serine/threonine protein kinases participating in ion homeostasis via the WNK-OSR1/SPAK-NKCC cascade. Recent studies of WNK1 have revealed that its related signaling pathways mediated tumor-induced angiogenesis and carcinogenesis and uncovered novel roles of WNK1 in endothelial cell migration and proliferation, tumor cell proliferation, and metastasis. Herein, we review the functions of WNK1 in cancer metastasis and angiogenesis and propose WNK1 targeting as an anti-cancer strategy.
无赖氨酸激酶（WNKs）是参与离子稳态的丝氨酸/苏氨酸蛋白激酶的一个新家族，通过 WNK-OSR1/SPAK-NKCC 级联反应。最近对 WNK1 的研究揭示了其相关信号通路介导肿瘤诱导的血管生成和癌变，并揭示了 WNK1 在血管内皮细胞迁移和增殖、肿瘤细胞增殖和转移中的新作用。本文综述了 WNK1 在肿瘤转移和血管生成中的作用，并提出了靶向 WNK1 作为一种抗癌策略。
Zotero 插件