Thulin L, Johansson C
Acta Chir Scand Suppl. 1978;482:69-72.
The chemistry, localisation, release and effects of gastrointestinal hormones and some related peptides are surveyed. Their main presumed physiologic actions are: gastric acid and pepsin secretion are stimulated by gastrin and to a less degree by secretin. Acid secretion is inhibited by bulbo-enterogastrone and GIP. Biliary water and electrolytes are augmented by gastrin, CCK-PZ, secretin and VIP and inhibited by Substance P. Pancreatic bicarbonate and enzyme secretions are stimulated by secretin and CCK-PZ, especially in combination. Lower oesophageal and antral motility and tonus are elevated following gastrin and motilin; the gallbladder and small intestine empty following CCK. Gastrin regulates gastrointestinal, and CCK pancreatic, tissue growth. Somatostatin inhibits all gut hormones. All peptides are vasoactive within the splanchnic area, each one in a specific manner.
本文综述了胃肠激素及一些相关肽类的化学性质、定位、释放和作用。它们主要的假定生理作用如下：胃泌素刺激胃酸和胃蛋白酶分泌，促胰液素在较小程度上也有此作用。球抑胃素和胃抑肽抑制胃酸分泌。胃泌素、缩胆囊素-促胰酶素、促胰液素和血管活性肠肽可增加胆汁中的水和电解质含量，P物质则起抑制作用。促胰液素和缩胆囊素-促胰酶素，尤其是两者联合作用时，可刺激胰腺分泌碳酸氢盐和酶。胃泌素和胃动素可增强食管下段和胃窦的运动及紧张性；缩胆囊素可促使胆囊和小肠排空。胃泌素调节胃肠道组织生长，缩胆囊素调节胰腺组织生长。生长抑素抑制所有胃肠激素。所有这些肽类在腹腔区域均有血管活性，各有其特定方式。
Zotero 插件