临床内分泌学与代谢。胆囊收缩素。

Clinical endocrinology and metabolism. Cholecystokinin.

作者信息

Rehfeld Jens F

机构信息

Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.

出版信息

Best Pract Res Clin Endocrinol Metab. 2004 Dec;18(4):569-86. doi: 10.1016/j.beem.2004.07.002.

DOI:10.1016/j.beem.2004.07.002

PMID:15533776

Abstract

Cholecystokinin (CCK) is a peptide hormone discovered in the small intestine. Together with secretin and gastrin, CCK constitutes the classical gut hormone triad. In addition to gallbladder contraction, CCK also regulates pancreatic enzyme secretion and growth, intestinal motility, satiety signalling and the inhibition of gastric acid secretion. CCK is, however, also a transmitter in central and intestinal neurons. Notably, CCK is the most abundant neuropeptide in the human brain. Owing to difficulties in developing accurate assays, knowledge about CCK secretion in disease is limited. Available data indicate, however, that proCCK is expressed in certain neuroendocrine tumours and sarcomas, whereas the secretion of CCK is impaired in celiac disease and bulimia nervosa. Stimulation with exogenous CCK has proved useful in diagnostic tests of gallbladder and pancreatic diseases, as well as medullary thyroid carcinomas.

摘要

胆囊收缩素（CCK）是一种在小肠中发现的肽类激素。CCK与促胰液素和胃泌素共同构成经典的肠道激素三联体。除了引起胆囊收缩外，CCK还调节胰腺酶的分泌和生长、肠道蠕动、饱腹感信号以及胃酸分泌的抑制。然而，CCK也是中枢和肠道神经元中的一种递质。值得注意的是，CCK是人类大脑中含量最丰富的神经肽。由于开发准确检测方法存在困难，关于疾病中CCK分泌的知识有限。然而，现有数据表明，前CCK在某些神经内分泌肿瘤和肉瘤中表达，而在乳糜泻和神经性贪食症中CCK的分泌受损。外源性CCK刺激已被证明在胆囊和胰腺疾病以及甲状腺髓样癌的诊断测试中有用。