Department of Infectious Diseases, Aarhus University Hospital, Aarhus University, Aarhus, Denmark.
Department of Infectious Diseases, Aarhus University Hospital, Aarhus University, Aarhus, Denmark, Department of Public Health, Center for Global Health (GloHAU), Aarhus University, Aarhus, Denmark.
Int J Tuberc Lung Dis. 2022 Jun 1;26(6):516-523. doi: 10.5588/ijtld.21.0305.
is acid-fast and able to survive in the gastrointestinal tract. Thus, bacteria can be found in stool if sputum is swallowed. In this study, the accuracy of different diagnostic stool methods (microscopy, polymerase chain reaction PCR and culture) among adults with pulmonary TB (PTB) were assessed and compared with sputum culture. Embase and PubMed were searched to identify studies with data on stool testing among patients with clinically presumed or microbiologically verified PTB. Thirteen relevant studies were included. A pooled sensitivity of one or more of the three TB identifying methods was 79.1% (95% CI 61.5-92.5). The sensitivity of stool microscopy, PCR and culture was respectively 41.1% (95%CI 24.9-58.2), 89.7% (95% CI 81.4-95.9) and 38.0% (95% CI 26.2-50.6). The heterogeneity of the studies included was high. Our review findings indicate that the analysis of stool specimens as part of PTB diagnostics is useful. PCR methods were particularly helpful in detecting a substantial proportion of patients with PTB.
其具有抗酸性，能够在胃肠道中存活。因此，如果痰液被吞咽，粪便中可发现细菌。在这项研究中，评估了不同诊断性粪便方法（显微镜检查、聚合酶链反应（PCR）和培养）在成人肺结核（PTB）中的准确性，并与痰液培养进行了比较。检索 Embase 和 PubMed 以确定在临床疑似或微生物学证实的 PTB 患者中具有粪便检测数据的研究。共纳入 13 项相关研究。一种或多种三种结核病鉴定方法的汇总敏感性为 79.1%（95%CI 61.5-92.5）。粪便显微镜检查、PCR 和培养的敏感性分别为 41.1%（95%CI 24.9-58.2）、89.7%（95%CI 81.4-95.9）和 38.0%（95%CI 26.2-50.6）。纳入研究的异质性很高。我们的综述结果表明，分析粪便标本作为 PTB 诊断的一部分是有用的。PCR 方法特别有助于检测大量 PTB 患者。
